EP 3966211 A1 20220316 - MACROCYCLIC CHELATORS AND METHODS OF USE THEREOF
Title (en)
MACROCYCLIC CHELATORS AND METHODS OF USE THEREOF
Title (de)
MAKROCYCLISCHE CHELATBILDNER UND VERFAHREN ZU IHRER VERWENDUNG
Title (fr)
CHÉLATEURS MACROCYCLIQUES ET LEURS PROCÉDÉS D'UTILISATION
Publication
Application
Priority
- US 201962846044 P 20190510
- IB 2020054381 W 20200508
Abstract (en)
[origin: US2020353105A1] Macrocyclic chelators for chelation of alpha-emitting radiometal ions, such as actinium-225 are provided. Also provided are radiometal complexes containing an alpha-emitting radiometal ion bound to the macrocyclic chelator via coordinate bonding, and radioimmunoconjugates containing the radiometal complexes covalently linked to a targeting ligand, such as an antibody or antigen binding fragment thereof. The radioimmunoconjugates can be produced by click chemistry reactions. Methods of using the radiocomplexes and radioimmunoconjugates for selectively targeting neoplastic cells for radiotherapy and for treating neoplastic diseases and disorders are also described.
IPC 8 full level
C07D 413/06 (2006.01); A61K 31/4427 (2006.01); A61K 51/04 (2006.01); A61K 51/10 (2006.01); A61P 35/00 (2006.01); C07D 413/14 (2006.01)
CPC (source: EP IL KR US)
A61K 51/025 (2013.01 - IL US); A61K 51/0482 (2013.01 - IL KR US); A61K 51/1027 (2013.01 - IL KR US); A61K 51/1093 (2013.01 - IL KR US); A61P 35/00 (2018.01 - EP IL KR); C07D 413/06 (2013.01 - EP IL); C07D 413/14 (2013.01 - EP IL KR)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
US 11576986 B2 20230214; US 2020353105 A1 20201112; AU 2020273654 A1 20211125; BR 112021022237 A2 20220329; CA 3139806 A1 20201119; CL 2021002960 A1 20220624; CN 114127059 A 20220301; CN 114127059 B 20240924; CO 2021015713 A2 20211130; CR 20210556 A 20211217; DO P2021000233 A 20220731; EA 202193076 A1 20220216; EC SP21089217 A 20220131; EP 3966211 A1 20220316; IL 287909 A 20220101; JP 2022532157 A 20220713; KR 20220006613 A 20220117; MA 55885 A 20220316; MX 2021013667 A 20220131; PE 20220935 A1 20220531; SG 11202112100P A 20211129; US 2023110178 A1 20230413; WO 2020229974 A1 20201119
DOCDB simple family (application)
US 202016869771 A 20200508; AU 2020273654 A 20200508; BR 112021022237 A 20200508; CA 3139806 A 20200508; CL 2021002960 A 20211109; CN 202080050202 A 20200508; CO 2021015713 A 20211123; CR 20210556 A 20200508; DO 2021000233 A 20211110; EA 202193076 A 20200508; EC DI202189217 A 20211209; EP 20727846 A 20200508; IB 2020054381 W 20200508; IL 28790921 A 20211108; JP 2021566438 A 20200508; KR 20217040423 A 20200508; MA 55885 A 20200508; MX 2021013667 A 20200508; PE 2021001868 A 20200508; SG 11202112100P A 20200508; US 202217810316 A 20220630