Global Patent Index - EP 3976108 A4

EP 3976108 A4 20230719 - FUNCTIONALIZED FULLERENE GEL TUMOR TREATMENT

Title (en)

FUNCTIONALIZED FULLERENE GEL TUMOR TREATMENT

Title (de)

TUMORBEHANDLUNG MIT FUNKTIONALISIERTEM FULLERENGEL

Title (fr)

TRAITEMENT DE TUMEUR PAR GEL DE FULLERÈNE FONCTIONNALISÉ

Publication

EP 3976108 A4 20230719 (EN)

Application

EP 20814934 A 20200529

Priority

  • US 2020035063 W 20200529
  • US 201962855107 P 20190531

Abstract (en)

[origin: WO2020243390A1] Provided herein are compositions, systems, kits, and methods for administering a gel composition into a tumor of a subject and treating with laser light (e.g., for photoacoustic destruction of the tumor and tumor debris generation), where the gel comprises functionalized fullerenes (FFs) and a biocompatible polymer. In certain embodiments, 0.1-5% (e.g., about 1-2%) by weight of the gel is the functionalized fullerenes (e.g., polyhydroxy fullerenes). In other embodiments, the FFs have a generally symmetrical spherical structure.

IPC 8 full level

A61K 41/00 (2020.01); A61K 47/06 (2006.01); A61N 5/067 (2006.01); A61P 35/00 (2006.01); B82Y 30/00 (2011.01); C01B 32/152 (2017.01)

CPC (source: EP US)

A61K 9/0019 (2013.01 - US); A61K 9/06 (2013.01 - US); A61K 41/0028 (2013.01 - EP US); A61K 47/12 (2013.01 - US); A61P 35/00 (2017.12 - EP US); B82Y 30/00 (2013.01 - EP); C01B 32/152 (2017.07 - EP)

Citation (search report)

  • [X] WO 2009059215 A1 20090507 - UNIV FLORIDA [US], et al
  • [Y] CN 103191427 A 20130710 - UNIV ZHENGZHOU
  • [X] SOL KIM ET AL: "Acid pH-activated glycol chitosan/fullerene nanogels for efficient tumor therapy", CARBOHYDRATE POLYMERS, vol. 101, 9 October 2013 (2013-10-09), pages 692 - 698, XP055105050, ISSN: 0144-8617, DOI: 10.1016/j.carbpol.2013.09.108
  • [Y] TANIMOTO SHUHO ET AL: "Target-selective photo-degradation of HIV-1 protease by a fullerene-sugar hybrid", CHEMICAL COMMUNICATIONS, no. 44, 2 October 2008 (2008-10-02), pages 5767 - 5769, XP093052170, ISSN: 1359-7345, DOI: 10.1039/b811726h
  • [Y] YU-CHENG CHEN ET AL: "Non-metallic nanomaterials in cancer theranostics: a review of silica- and carbon-based drug delivery systems", SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS, vol. 14, no. 4, 12 March 2013 (2013-03-12), pages 044407, XP055523159, ISSN: 1468-6996, DOI: 10.1088/1468-6996/14/4/044407
  • [Y] CHEN ZHIYUN ET AL: "Applications of Functionalized Fullerenes in Tumor Theranostics", THERANOSTICS, vol. 2, no. 3, 1 March 2012 (2012-03-01), pages 238 - 250, XP093052379, ISSN: 1838-7640, DOI: 10.7150/thno.3509
  • [Y] WANG JING ET AL: "Visible light-switched cytosol release of siRNA by amphiphilic fullerene derivative to enhance RNAi efficacy in vitro and in vivo", ACTA BIOMATERIALIA, vol. 59, 13 May 2017 (2017-05-13), pages 158 - 169, XP093052560, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.05.031
  • See references of WO 2020243390A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2020243390 A1 20201203; EP 3976108 A1 20220406; EP 3976108 A4 20230719; US 2022233694 A1 20220728

DOCDB simple family (application)

US 2020035063 W 20200529; EP 20814934 A 20200529; US 202017612115 A 20200529