EP 3980439 A4 20230719 - ENDOCYTOSIS ROUTING SEQUENCE PEPTIDE FOR CELL DELIVERY SYSTEMS
Title (en)
ENDOCYTOSIS ROUTING SEQUENCE PEPTIDE FOR CELL DELIVERY SYSTEMS
Title (de)
ENDOCYTOSE-LEITSEQUENZPEPTID FÜR ZELLABGABESYSTEME
Title (fr)
PEPTIDE SÉQUENCE DE ROUTAGE PAR LA VOIE DE L'ENDOCYTOSE POUR DES SYSTÈMES D'ADMINISTRATION À DES CELLULES
Publication
Application
Priority
- HU P1900205 A 20190607
- HU 2020050023 W 20200608
Abstract (en)
[origin: US2022389057A1] The present invention relates to cell delivery systems. The present invention specifically relates to new methods of intracellular delivery by endocytosis routing sequence peptides having the sequence of WYKYV or analogues thereof, by caveloar/lipid raft-mediated endocytosis and uses of such peptides. The invention also relates to conjugates comprising said peptides and uses thereof in therapies wherein intracellular delivery of a therapeutically active molecule is required.
IPC 8 full level
C07K 7/00 (2006.01); A61K 38/00 (2006.01); A61K 47/00 (2006.01); C12N 5/00 (2006.01)
CPC (source: EP US)
A61K 9/127 (2013.01 - EP US); A61K 9/1273 (2013.01 - EP); A61K 9/5146 (2013.01 - EP US); C07K 7/06 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US)
Citation (search report)
- [YA] ANDRE S ET AL: "Identification of peptide ligands for malignancy- and growth-regulating galectins using random phage-display and designed combinatorial peptide libraries", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 13, no. 2, 17 January 2005 (2005-01-17), pages 563 - 573, XP027637825, ISSN: 0968-0896, [retrieved on 20050117]
- [YA] EDIT WÉBER ET AL: "Galectin-1-Asialofetuin Interaction Is Inhibited by Peptides Containing the Tyr-Xxx-Tyr Motif Acting on the Glycoprotein", CHEMBIOCHEM, JOHN WILEY & SONS, INC, HOBOKEN, USA, vol. 11, no. 2, 24 November 2009 (2009-11-24), pages 228 - 234, XP072152345, ISSN: 1439-4227, DOI: 10.1002/CBIC.200900502
- [A] QI RONG ET AL: "The Mechanism of Polyplex Internalization into Cells: Testing the GM1/Caveolin-1 Lipid Raft Mediated Endocytosis Pathway", MOLECULAR PHARMACEUTICS, vol. 7, no. 1, 1 February 2010 (2010-02-01), US, pages 267 - 279, XP093052656, ISSN: 1543-8384, DOI: 10.1021/mp900241t
- [A] SIWARUTT BOONYARATTANAKALIN ET AL: "Synthetic Mimics of Small Mammalian Cell Surface Receptors", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 126, no. 50, 1 December 2004 (2004-12-01), pages 16379 - 16386, XP055382583, ISSN: 0002-7863, DOI: 10.1021/ja046663o
- See references of WO 2020245617A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
US 2022389057 A1 20221208; EP 3980439 A1 20220413; EP 3980439 A4 20230719; WO 2020245617 A1 20201210
DOCDB simple family (application)
US 202017616770 A 20200608; EP 20817891 A 20200608; HU 2020050023 W 20200608