EP 3980540 A4 20231101 - METHODS FOR THE TREATMENT OF ALPHA-1 ANTITRYPSIN DEFICIENCY (AATD)
Title (en)
METHODS FOR THE TREATMENT OF ALPHA-1 ANTITRYPSIN DEFICIENCY (AATD)
Title (de)
VERFAHREN ZUR BEHANDLUNG VON ALPHA-1-ANTITRYPSIN-MANGEL (AATD)
Title (fr)
MÉTHODES DE TRAITEMENT D'UNE DÉFICIENCE EN ALPHA-1 ANTITRYPSINE (AATD)
Publication
Application
Priority
- US 201962858059 P 20190606
- US 2020036359 W 20200605
Abstract (en)
[origin: WO2020247774A1] Described are methods for treating alpha- 1 antitrypsin deficiency (AATD) in a human patient in need of treatment, using pharmaceutical compositions that include AAT RNAi agents. The pharmaceutical compositions disclosed herein that include AAT RNAi agents, when administered to a human patient in need thereof, treat liver diseases associated with AAT deficiency such as chronic hepatitis, cirrhosis, increased risk of hepatocellular carcinoma, transaminitis, cholestasis, fibrosis, fulminant hepatic failure, and other liver-related diseases.
IPC 8 full level
C12N 15/113 (2010.01); A61K 31/712 (2006.01); A61K 31/7125 (2006.01); A61K 31/713 (2006.01); A61P 1/16 (2006.01); A61P 11/00 (2006.01)
CPC (source: EP KR US)
A61K 9/0019 (2013.01 - EP KR); A61K 31/713 (2013.01 - EP KR US); A61K 45/06 (2013.01 - EP KR US); A61K 47/02 (2013.01 - EP); A61K 48/00 (2013.01 - KR); A61P 1/16 (2018.01 - EP KR US); A61P 11/00 (2018.01 - EP); C12N 15/113 (2013.01 - EP KR); A61K 2300/00 (2013.01 - KR); C12N 2310/315 (2013.01 - EP KR); C12N 2310/321 (2013.01 - EP KR); C12N 2310/322 (2013.01 - EP KR); C12N 2310/332 (2013.01 - EP KR); C12N 2310/343 (2013.01 - EP KR); C12N 2310/344 (2013.01 - EP KR); C12N 2310/346 (2013.01 - EP KR); C12N 2310/3515 (2013.01 - EP KR); C12N 2310/3521 (2013.01 - KR); C12N 2310/3533 (2013.01 - KR)
C-Set (source: EP)
Citation (search report)
[ID] WO 2018132432 A1 20180719 - ARROWHEAD PHARMACEUTICALS INC [US]
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2020247774 A1 20201210; AU 2020286462 A1 20220127; BR 112021024534 A2 20220208; CA 3141762 A1 20201210; CN 114222820 A 20220322; CO 2022000016 A2 20220408; EP 3980540 A1 20220413; EP 3980540 A4 20231101; JP 2022535127 A 20220804; KR 20220019255 A 20220216; MX 2021015003 A 20220124; TW 202113081 A 20210401; US 2022305046 A1 20220929
DOCDB simple family (application)
US 2020036359 W 20200605; AU 2020286462 A 20200605; BR 112021024534 A 20200605; CA 3141762 A 20200605; CN 202080041338 A 20200605; CO 2022000016 A 20220104; EP 20818171 A 20200605; JP 2021572103 A 20200605; KR 20227000043 A 20200605; MX 2021015003 A 20200605; TW 109119068 A 20200605; US 202017616292 A 20200605