Global Patent Index - EP 3984535 A1

EP 3984535 A1 20220420 - NLRP3 ACTIVATORS FOR USE IN THE TREATMENT OF INFECTIOUS DISEASES OR CANCER BY ACTIVATING NLRP3 INFLAMMASOME

Title (en)

NLRP3 ACTIVATORS FOR USE IN THE TREATMENT OF INFECTIOUS DISEASES OR CANCER BY ACTIVATING NLRP3 INFLAMMASOME

Title (de)

NLRP3-AKTIVATOREN ZUR BEHANDLUNG VON INFEKTIONSKRANKHEITEN ODER KREBS DURCH AKTIVIERUNG DES NLRP3-INFLAMMASOMS

Title (fr)

ACTIVATEURS DE NLRP3 À UTILISER DANS LE TRAITEMENT DES MALADIES INFECTIEUSES OU DU CANCER EN ACTIVANT L'INFLAMMASOME NLRP3

Publication

EP 3984535 A1 20220420 (EN)

Application

EP 20202297 A 20201016

Priority

EP 20202297 A 20201016

Abstract (en)

The present invention relates to a compound or pharmaceutically acceceptable salts thereof, that modulates NLRP3 in that the NLRP3 inflammasome is activated. This invention further relates to the compounds and/or compositions for use in the prevention and treatment of a condition, disease or a disorder by activating NLRP3 inflammasome, wherein the disease is selected from a group comprising infectious diseases, or cancer. Moreover, the invention relates to the use of the present compounds for analyzing the activity of NLRP3 activation.

IPC 8 full level

A61K 31/4245 (2006.01); A61K 31/00 (2006.01); A61K 31/17 (2006.01); A61K 31/341 (2006.01); A61K 31/47 (2006.01); A61K 31/4709 (2006.01); A61P 31/00 (2006.01); A61P 35/00 (2006.01); A61P 37/04 (2006.01)

CPC (source: EP US)

A61K 31/00 (2013.01 - EP); A61K 31/17 (2013.01 - EP US); A61K 31/277 (2013.01 - US); A61K 31/341 (2013.01 - EP US); A61K 31/351 (2013.01 - US); A61K 31/397 (2013.01 - US); A61K 31/402 (2013.01 - US); A61K 31/404 (2013.01 - US); A61K 31/4178 (2013.01 - US); A61K 31/421 (2013.01 - US); A61K 31/4245 (2013.01 - EP US); A61K 31/433 (2013.01 - US); A61K 31/4375 (2013.01 - US); A61K 31/4439 (2013.01 - US); A61K 31/47 (2013.01 - EP); A61K 31/4709 (2013.01 - EP US); A61K 31/5375 (2013.01 - US); A61P 31/00 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 37/04 (2018.01 - EP US)

Citation (applicant)

  • US 2019127368 A1 20190502 - GLICK GARY D [US], et al
  • WO 2014189805 A1 20141127 - AURO BIOTECH INC [US], et al
  • US 7927613 B2 20110419 - ALMARSSON OERN [US], et al
  • CHRISTINA J. GROGRITU MISHRAKATHARINA S. SCHNEIDERGUILLAUME MEDARDJENNIFER WETTMARSHAUSENDANIELA C. DITTLEINHEXIN SHIOLIVER GORKAP: "K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria", IMMUNITY, vol. 45, 18 October 2016 (2016-10-18), pages 761 - 773, XP029771331, DOI: 10.1016/j.immuni.2016.08.010
  • GROSSOLAF: "Measuring the inflammasome", METHODS IN MOLECULAR BIOLOGY, CLIFTON, N.J., vol. 844, 2012, pages 199 - 222
  • "Pharmaceutical Preformulation and Formulation", 2009, THE PHARMACEUTICAL PRESS AND THE AMERICAN PHARMACEUTICAL ASSOCIATION
  • "Handbook of Pharmaceutical Additives", 2007, GOWER PUBLISHING COMPANY
  • LAMMERS ET AL.: "Effect of Intratumoral Injection on the Biodistribution and the Therapeutic Potential of HPMA Copolymer-Based Drug Delivery Systems", NEOPLASIA, vol. 10, 2006, pages 788 - 795
  • FILIPSKI, K.J. ET AL., CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 13, 2013, pages 776 - 802
  • POSTOW, M. J. CLIN. ONCOL., vol. 33, 2015, pages 1
  • MARIATHASAN, S.NEWTON, K.MONACK, D ET AL.: "Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf", NATURE, vol. 430, 2004, pages 213 - 218, Retrieved from the Internet <URL:https://doi.org/10.1038/nature02664>
  • SCHNEIDER, KATHARINA S.THOMAS, CHRISTINA J.GROGOLAF: "Inflammasome activation and inhibition in primary murine bone marrow-derived cells, and assays for IL-1a, L-13, and caspase-1", METHODS IN MOLECULAR BIOLOGY, CLIFTON, N.J., vol. 1040, 2013, pages 117 - 135

Citation (search report)

  • [X] WO 2019209896 A1 20191031 - INNATE TUMOR IMMUNITY INC [US]
  • [A] WO 2018167468 A1 20180920 - NODTHERA LTD [GB]
  • [A] WO 2020102576 A1 20200522 - NOVARTIS INFLAMMASOME RES INC [US]
  • [X] WO 2020104657 A1 20200528 - INFLAZOME LTD [IE]
  • [X] JP 2017197534 A 20171102 - ONO PHARMACEUTICAL CO
  • [X] KR 20190026154 A 20190313 - UNIV YEUNGNAM RES COOPERATION FOUNDATION [KR]
  • [X] WO 2018150302 A1 20180823 - DISTRETTO TECNOLOGICO SICILIA MICRO E NANO SISTEMI S C A R L [IT]
  • [X] WO 2019010293 A1 20190110 - DIGNITY HEALTH [US]
  • [X] CN 109893528 A 20190618 - UNIV FUJIAN MEDICAL
  • [X] KUMAR K SANTOSH ET AL: "Synthesis and antimicrobial evaluation of novel urea derivatives from chromene based oxadiazole amines", MEDICINAL CHEMISTRY RESEARCH, BIRKHAEUSER, BOSTON, US, vol. 25, no. 10, 26 July 2016 (2016-07-26), pages 2179 - 2186, XP036081690, ISSN: 1054-2523, [retrieved on 20160726], DOI: 10.1007/S00044-016-1651-6
  • [X] BOZDAG MURAT ET AL: "Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX", JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, no. 14, 2 July 2018 (2018-07-02), pages 6328 - 6338, XP055790628, ISSN: 0022-2623, Retrieved from the Internet <URL:https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00770> DOI: 10.1021/acs.jmedchem.8b00770
  • [X] DATABASE Registry [online] 1 January 2004 (2004-01-01), ANONYMOUS: "683206-01-1", XP055790629, Database accession no. 683206-01-1
  • [X] DATABASE Registry [online] 1 January 2011 (2011-01-01), ANONYMOUS: "2,4-Imidazolidinedione, 1-(4-fluorophenyl)-5-methyl-3-[[3-(4-methylphenyl)- 1,2,4-oxadiazol-5-yl]methyl]-", XP055790630, Database accession no. 1277156-39-4
  • [X] DATABASE Registry [online] 1 January 2011 (2011-01-01), ANONYMOUS: "Urea, N-(3-chloro-2,6-diethylphenyl)-N'-[2-methyl-1-[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl]propyl]-", XP055790631, Database accession no. 1311951-62-8

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

EP 3984535 A1 20220420; EP 4228630 A1 20230823; US 2024277658 A1 20240822; WO 2022079246 A1 20220421

DOCDB simple family (application)

EP 20202297 A 20201016; EP 2021078623 W 20211015; EP 21794528 A 20211015; US 202118030875 A 20211015