EP 3990495 A4 20231108 - ANTIBODIES FOR T-CELL ACTIVATION
Title (en)
ANTIBODIES FOR T-CELL ACTIVATION
Title (de)
ANTIKÖRPER ZUR AKTIVIERUNG VON T-ZELLEN
Title (fr)
ANTICORPS POUR L'ACTIVATION DE LYMPHOCYTES T
Publication
Application
Priority
- US 201962866699 P 20190626
- US 201962953302 P 20191224
- US 2020039218 W 20200624
Abstract (en)
[origin: US2020407456A1] Antibodies that include an antigen binding region that binds to CD137 are provided herein. Also provided herein are bispecific antibodies that include a first antigen binding region that binds to CD137 and a second antigen binding region that binds to an immune checkpoint molecule, an immune stimulatory molecule, or a tumor antigen. Pharmaceutical compositions that include the antibodies and methods of treating cancer are provided.
IPC 8 full level
C07K 16/28 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP KR US)
A61K 47/6803 (2017.07 - KR); A61P 35/00 (2017.12 - EP KR); C07K 16/2827 (2013.01 - EP US); C07K 16/2878 (2013.01 - EP KR US); A61K 2039/505 (2013.01 - EP KR US); C07K 2317/21 (2013.01 - EP); C07K 2317/31 (2013.01 - EP KR US); C07K 2317/51 (2013.01 - US); C07K 2317/515 (2013.01 - US); C07K 2317/52 (2013.01 - US); C07K 2317/56 (2013.01 - US); C07K 2317/565 (2013.01 - US); C07K 2317/622 (2013.01 - EP KR US); C07K 2317/73 (2013.01 - KR); C07K 2317/75 (2013.01 - EP KR US); C07K 2317/76 (2013.01 - US); C07K 2317/77 (2013.01 - EP KR); C07K 2317/92 (2013.01 - EP KR); C07K 2317/94 (2013.01 - EP)
Citation (search report)
- [I] EP 3470428 A1 20190417 - NUMAB INNOVATION AG [CH]
- [I] WO 2019091436 A1 20190516 - SHANGHAI PHARMAEXPLORER CO LTD [CN]
- [I] US 2017198050 A1 20170713 - ECKELMAN BRENDAN P [US], et al
- [I] WO 2018156740 A1 20180830 - MACROGENICS INC [US]
- [I] WO 2018091740 A2 20180524 - ALLIGATOR BIOSCIENCE AB [SE]
- [I] WO 2019089753 A2 20190509 - COMPASS THERAPEUTICS LLC [US]
- [I] MARTA COMPTE ET AL: "A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity", NATURE COMMUNICATIONS, vol. 9, no. 1, 15 November 2018 (2018-11-15), XP055611095, DOI: 10.1038/s41467-018-07195-w
- See references of WO 2020263879A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
US 11725058 B2 20230815; US 2020407456 A1 20201231; AU 2020308463 A1 20220217; BR 112021026309 A2 20220607; CA 3144617 A1 20201230; CN 114514244 A 20220517; EP 3990495 A1 20220504; EP 3990495 A4 20231108; JP 2022539527 A 20220912; KR 20220025739 A 20220303; TW 202108629 A 20210301; US 2024026018 A1 20240125; WO 2020263879 A1 20201230; WO 2020263879 A9 20211202
DOCDB simple family (application)
US 202016911052 A 20200624; AU 2020308463 A 20200624; BR 112021026309 A 20200624; CA 3144617 A 20200624; CN 202080045146 A 20200624; EP 20831405 A 20200624; JP 2021576891 A 20200624; KR 20217042095 A 20200624; TW 109121449 A 20200624; US 2020039218 W 20200624; US 202318222763 A 20230717