EP 3990626 A1 20220504 - CHIMERIC ANTIGEN RECEPTOR WITH 4-1BB COSTIMULATORY DOMAIN
Title (en)
CHIMERIC ANTIGEN RECEPTOR WITH 4-1BB COSTIMULATORY DOMAIN
Title (de)
CHIMÄRER ANTIGENREZEPTOR MIT 4-1BB-KOSTIMULATORISCHER DOMÄNE
Title (fr)
RÉCEPTEUR ANTIGÈNIQUE CHIMÈRIQUE AYANT UN DOMAINE DE COSTIMULATION 4-1BB
Publication
Application
Priority
- US 201962867503 P 20190627
- KR 2019010244 W 20190812
- US 201916715462 A 20191216
- US 202062991493 P 20200318
- US 202063004827 P 20200403
- US 202063043237 P 20200624
- IB 2020056097 W 20200626
Abstract (en)
[origin: WO2020261231A1] Provided are CAR-T compositions that are directed to a CAR including (i) an extracellular domain comprising an antigen-binding domain; (ii) a transmembrane domain; and (iii) an intracellular domain comprising a costimulatory endodomain, wherein the costimulatory endodomain comprises an intracellular signaling domain from 4-1BB/CD137 and five additional amino acids. The disclosure also provides vectors, compositions, and methods of treatment using the antigen binding molecules and engineered immune cells comprising the CAR. The CAR compositions provided herein can be used for the treatment of certain cancers.
IPC 8 full level
C12N 5/0783 (2010.01); A61K 35/17 (2015.01); A61P 35/00 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01)
CPC (source: CN EP KR)
A61K 39/4611 (2023.05 - CN EP KR); A61K 39/4631 (2023.05 - CN EP KR); A61K 39/464412 (2023.05 - CN EP KR); A61K 39/464474 (2023.05 - CN EP KR); A61P 35/00 (2018.01 - CN EP); C07K 14/7051 (2013.01 - CN EP KR); C07K 14/70517 (2013.01 - CN EP); C07K 14/70578 (2013.01 - CN EP); C07K 16/28 (2013.01 - CN); C07K 16/2803 (2013.01 - CN EP); C07K 16/303 (2013.01 - CN EP); C12N 5/0636 (2013.01 - CN EP KR); C12N 5/0646 (2013.01 - CN EP KR); C12N 15/625 (2013.01 - KR); C12N 15/85 (2013.01 - KR); C12N 15/86 (2013.01 - CN); A61K 2239/31 (2023.05 - CN EP KR); A61K 2239/38 (2023.05 - CN EP KR); C07K 2317/24 (2013.01 - KR); C07K 2317/622 (2013.01 - EP KR); C07K 2317/73 (2013.01 - EP); C07K 2319/00 (2013.01 - EP); C07K 2319/02 (2013.01 - CN EP KR); C07K 2319/03 (2013.01 - CN EP KR); C07K 2319/33 (2013.01 - CN EP); C07K 2319/43 (2013.01 - CN EP); C07K 2319/74 (2013.01 - CN); C12N 2510/00 (2013.01 - CN KR); C12N 2740/16043 (2013.01 - CN EP KR); C12N 2800/107 (2013.01 - CN)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2020261231 A1 20201230; AU 2020307673 A1 20220120; BR 112021026406 A2 20220412; CA 3144875 A1 20201230; CN 114080452 A 20220222; EP 3990626 A1 20220504; EP 3990626 A4 20230920; JP 2022538425 A 20220902; KR 20220030248 A 20220310; MX 2021015967 A 20220406
DOCDB simple family (application)
IB 2020056097 W 20200626; AU 2020307673 A 20200626; BR 112021026406 A 20200626; CA 3144875 A 20200626; CN 202080047355 A 20200626; EP 20831651 A 20200626; JP 2021576820 A 20200626; KR 20227001944 A 20200626; MX 2021015967 A 20200626