EP 3994154 A1 20220511 - STREPTOMYCES CLAVULIGERUS
Title (en)
STREPTOMYCES CLAVULIGERUS
Title (de)
STREPTOMYCES CLAVULIGERUS
Title (fr)
STREPTOMYCES CLAVULIGERUS
Publication
Application
Priority
- GB 201909698 A 20190705
- GB 202005327 A 20200409
- EP 2020068761 W 20200703
Abstract (en)
[origin: WO2021004912A1] The invention relates to a Streptomyces clavuligerus strain comprising two point mutations in a ccaR promoter region and a substitution mutation in the ccaR gene, wherein the mutations in the ccaR promoter region are a C to T point mutation at a site corresponding to position 48 of SEQ ID NO:1 and a G to A point mutation at a site corresponding to position 143 of SEQ ID NO:1; and wherein the mutation in the ccaR gene is an arginine to tryptophan substitution at a site corresponding to position 32 of SEQ ID NO: 2. The invention also relates to a method of using said Streptomyces clavuligerus strain for producing clavulanic acid.
IPC 8 full level
C07K 14/36 (2006.01); C12P 17/18 (2006.01)
CPC (source: CN EP KR)
A61K 31/424 (2013.01 - CN KR); A61K 31/43 (2013.01 - CN KR); A61P 31/04 (2017.12 - CN KR); C07K 14/36 (2013.01 - CN EP KR); C12N 1/20 (2013.01 - CN KR); C12N 15/76 (2013.01 - CN KR); C12P 17/18 (2013.01 - CN); C12P 17/188 (2013.01 - CN EP KR); C12R 2001/465 (2021.05 - KR)
Citation (search report)
See references of WO 2021004912A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2021004912 A1 20210114; CN 114072493 A 20220218; EP 3994154 A1 20220511; KR 20220031043 A 20220311; MX 2022000250 A 20220203
DOCDB simple family (application)
EP 2020068761 W 20200703; CN 202080048999 A 20200703; EP 20737125 A 20200703; KR 20227003395 A 20200703; MX 2022000250 A 20200703