EP 3995509 A1 20220511 - METHOD FOR INDUCING NEURONAL SYNAPSE FORMATION AND MICROBEADS USED IN SAID METHOD
Title (en)
METHOD FOR INDUCING NEURONAL SYNAPSE FORMATION AND MICROBEADS USED IN SAID METHOD
Title (de)
VERFAHREN ZUR INDUKTION EINER NEURONALEN SYNAPSENBILDUNG UND IN DIESEM VERFAHREN VERWENDETE MIKROKÜGELCHEN
Title (fr)
PROCÉDÉ INDUISANT LA FORMATION DE SYNAPSES NEURONALES ET MICROBILLES UTILISÉES DANS LEDIT PROCÉDÉ
Publication
Application
Priority
- JP 2019126416 A 20190705
- JP 2020025313 W 20200626
Abstract (en)
An object of the present invention is to provide a method for inducing the formation of the presynaptic apparatus in human neurons.According to the present invention, a method for inducing the formation of the presynaptic apparatus in human neurons, comprising co-culturing the peripheral neurons with microbeads in which at least one LRRTM molecule selected from the group consisting of the LRRTM (Leucine-rich repeat transmembrane neuronal protein) family molecules or a fusion protein containing the same is fixed to the surface (wherein, the LRRTM molecule or the fusion protein containing the same molecule is fixed to the surface of the microbead via a linker), and a microbead used for the method, are provided.
IPC 8 full level
C07K 14/705 (2006.01); C07K 16/00 (2006.01); C07K 17/06 (2006.01); C07K 19/00 (2006.01); C12M 1/00 (2006.01); C12M 3/00 (2006.01); C12N 5/0793 (2010.01)
CPC (source: EP US)
A61P 25/28 (2017.12 - US); C07K 14/705 (2013.01 - EP US); C07K 16/42 (2013.01 - EP); C12N 5/0619 (2013.01 - EP US); G01N 33/5058 (2013.01 - EP US); G01N 33/6896 (2013.01 - EP); C07K 2319/30 (2013.01 - EP US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
EP 3995509 A1 20220511; EP 3995509 A4 20230719; JP WO2021006075 A1 20210114; US 2023313132 A1 20231005; WO 2021006075 A1 20210114
DOCDB simple family (application)
EP 20837110 A 20200626; JP 2020025313 W 20200626; JP 2021530604 A 20200626; US 202017624506 A 20200626