EP 4010004 A4 20230913 - COMPOSITIONS AND METHODS FOR MODULATION OF GENE EXPRESSION
Title (en)
COMPOSITIONS AND METHODS FOR MODULATION OF GENE EXPRESSION
Title (de)
ZUSAMMENSETZUNGEN UND VERFAHREN ZUR MODULATION VON GENEXPRESSION
Title (fr)
COMPOSITIONS ET MÉTHODES DE MODULATION D'EXPRESSION GÉNIQUE
Publication
Application
Priority
- US 201962884028 P 20190807
- US 201962898434 P 20190910
- US 201962937011 P 20191118
- US 2020045174 W 20200806
Abstract (en)
[origin: WO2021026336A2] The present disclosure provides polypeptides, compositions thereof, and methods for suppressing expression of a target gene such as PDCD1, CTLA4, LAG3, or TIM-3. The polypeptides disclosed herein include a DNA binding domain (DBD) that binds to a sequence of the target gene and a transcriptional repressor domain that suppresses expression of the target gene. The transcriptional repressor domain may be a known transcriptional repressor or may be a novel transcriptional repressor disclosed herein. Also disclosed herein are novel transcriptional repressors that are conjugated to a heterologous DNA binding domain and mediate suppression of expression of a target gene bound by the DNA binding domain. Also disclosed herein are split systems for modulating gene expression where the DBD and the functional domain are provided as separated polypeptides and are assembled using dimerization of a heterodimer pair, where the DBD and the functional domain are each fused to a member of the heterodimer pair.
IPC 8 full level
A61K 38/00 (2006.01); C07K 14/195 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C07K 19/00 (2006.01); C12N 9/22 (2006.01); C12N 15/00 (2006.01); C12N 15/85 (2006.01)
CPC (source: EP)
C07K 14/7051 (2013.01); C07K 14/70521 (2013.01); C12N 15/85 (2013.01); C07K 14/70503 (2013.01); C07K 14/70596 (2013.01); C07K 2319/03 (2013.01); C07K 2319/71 (2013.01); C07K 2319/80 (2013.01); C07K 2319/81 (2013.01); C12N 9/22 (2013.01); C12N 2830/005 (2013.01)
Citation (search report)
- [I] WO 2017069958 A2 20170427 - BRIGHAM & WOMENS HOSPITAL INC [US], et al
- [I] WO 2014059173 A2 20140417 - SANGAMO BIOSCIENCES INC [US]
- [Y] WO 2017093969 A1 20170608 - NOVARTIS AG [CH], et al
- [Y] WO 2012104729 A1 20120809 - BONAS ULLA [DE], et al
- See references of WO 2021026336A2
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2021026336 A2 20210211; WO 2021026336 A3 20210311; EP 4010004 A2 20220615; EP 4010004 A4 20230913
DOCDB simple family (application)
US 2020045174 W 20200806; EP 20851042 A 20200806