EP 4017981 A1 20220629 - VARIANTS OF GALA REDUCTASE AND THEIR USES
Title (en)
VARIANTS OF GALA REDUCTASE AND THEIR USES
Title (de)
VARIANTEN DER GALAREDUKTASE UND DEREN VERWENDUNGEN
Title (fr)
VARIANTS DE GALA RÉDUCTASE ET LEURS UTILISATIONS
Publication
Application
Priority
- US 201962912195 P 20191008
- EP 2020078295 W 20201008
Abstract (en)
[origin: WO2021069602A1] The present invention relates to polypeptides which are galacturonate (GalA) reductase variants comprising at least one amino acid substitution at a position corresponding to K261 and/or R267. The present invention further relates to nucleic acid molecules encoding the polypeptides and to host cells containing said nucleic acid molecules. The present invention further relates to a method for the production of L-galactonate (GalOA) and/or other bio-based compounds, comprising the expression of said nucleic acid molecules, preferably in said host cells. The present invention also relates to the use of the polypeptides, nucleic acids molecule or host cells for the production of L-galactonate (GalOA) and/or other bio-based compounds, and/or for the recombinant fermentation of biomaterial containing D-galacturonate (GalA).
IPC 8 full level
C12N 15/52 (2006.01); C12N 9/04 (2006.01); C12P 7/00 (2006.01)
CPC (source: EP US)
C12N 9/0006 (2013.01 - EP US); C12N 15/52 (2013.01 - EP); C12N 15/81 (2013.01 - US); C12P 7/58 (2013.01 - EP US); C12P 17/06 (2013.01 - US); C12Y 101/01 (2013.01 - US); C12Y 101/01067 (2013.01 - US); C12N 2800/102 (2013.01 - US); C12P 7/06 (2013.01 - EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2021069602 A1 20210415; EP 4017981 A1 20220629; US 2024052387 A1 20240215
DOCDB simple family (application)
EP 2020078295 W 20201008; EP 20789084 A 20201008; US 202017766552 A 20201008