EP 4022313 A1 20220706 - IMMUNOHISTOCHEMICAL ASSESSMENT OF B7-H3 EXPRESSION
Title (en)
IMMUNOHISTOCHEMICAL ASSESSMENT OF B7-H3 EXPRESSION
Title (de)
IMMUNHISTOCHEMISCHE BEWERTUNG DER B7-H3-EXPRESSION
Title (fr)
ÉVALUATION IMMUNOHISTOCHIMIQUE DE L'EXPRESSION DE B7-H3
Publication
Application
Priority
- US 201962893883 P 20190830
- DK 2020050236 W 20200820
Abstract (en)
[origin: WO2021037319A1] The present invention relates to a method for providing a biomarker of the efficacy and/or safety of an antibody or antigen-binding fragment thereof using immunohistochemical methods. Former immunohistochemical methods using paraffin embedded samples in combination with a murine 8H9 antibody, have not provided satisfactory results. The present invention discloses a method that can use both frozen samples as well as paraffin embedded samples. Further, the present invention relates to a kit of parts adapted to carry out the inventive method. Moreover, the invention relates to a method of treating a cancer, comprising measuring or verifying a biomarker of the efficacy, the suitability and/or safety of an antibody or antigen-binding fragment thereof, wherein said antibody or antigen-binding fragment thereof is used for treating said cancer.
IPC 8 full level
G01N 33/574 (2006.01); C07K 16/28 (2006.01); G01N 1/28 (2006.01)
CPC (source: EP)
C07K 16/2827 (2013.01); G01N 1/36 (2013.01); G01N 1/42 (2013.01); G01N 33/574 (2013.01); G01N 1/06 (2013.01); G01N 1/30 (2013.01); G01N 2333/70596 (2013.01); G01N 2800/52 (2013.01)
Citation (search report)
See references of WO 2021037319A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2021037319 A1 20210304; EP 4022313 A1 20220706; TW 202208855 A 20220301
DOCDB simple family (application)
DK 2020050236 W 20200820; EP 20765196 A 20200820; TW 110105983 A 20210220