EP 4045500 A1 20220824 - PROCESS FOR PRODUCING ACYLOXYMETHYL ESTERS OF (4S)-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1,6-NAPHTHYRIDIN-3-CARBOXYLIC ACID
Title (en)
PROCESS FOR PRODUCING ACYLOXYMETHYL ESTERS OF (4S)-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1,6-NAPHTHYRIDIN-3-CARBOXYLIC ACID
Title (de)
VERFAHREN ZUR HERSTELLUNG VON ACYLOXYMETHYLESTERN DER (4S) -(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1,6-NAPHTHYRIDIN-3-CARBONSÄURE
Title (fr)
PROCÉDÉ DE PRODUCTION DES ESTERS ACYLOXYMÉTHYLES D'ACIDE (4S)-(4-CYANO-2-MÉTHOXYPHÉNYL)-5-ÉTHOXY-2,8-DIMÉTHYL-1,4-DIHYDRO-1,6-NAPHTYRIDIN-3-CARBOXYLIQUE
Publication
Application
Priority
- EP 19203821 A 20191017
- EP 2020078611 W 20201012
Abstract (en)
[origin: WO2021074077A1] The present invention relates to a process for producing acyloxymethyl esters of (4S)-(4-cyano- 2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carboxylic acid of formula (IIa) by chiral resolution of the compound of formula (II) using a hydrolase. The invention also relates to a process for producing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carboxamide of formula (Ia), said process comprising the chiral resolution of the compound of formula (II) using a hydrolase. In addition, the invention also relates to the use of a hydrolase in a process for producing a compound according to formula (IIa). The invention further relates to the use of a hydrolase in a process for producing a compound according to formula (Ia).
IPC 8 full level
C07D 471/04 (2006.01); C07B 57/00 (2006.01)
CPC (source: CN EP IL KR US)
C07B 57/00 (2013.01 - EP IL KR US); C07D 471/04 (2013.01 - CN EP IL KR US); C12N 9/20 (2013.01 - US); C12P 41/00 (2013.01 - CN US); C07B 2200/07 (2013.01 - KR US); C12Y 301/01003 (2013.01 - US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2021074077 A1 20210422; AU 2020365314 A1 20220512; BR 112022005605 A2 20220719; CA 3157823 A1 20210422; CL 2022000941 A1 20221111; CN 114555599 A 20220527; CN 114555599 B 20240607; CO 2022004464 A2 20220429; CR 20220161 A 20220617; EP 4045500 A1 20220824; IL 292194 A 20220601; JO P20220148 A1 20230130; JP 2022553225 A 20221222; KR 20220084102 A 20220621; MX 2022004480 A 20220506; PE 20221414 A1 20220920; US 2024150344 A1 20240509
DOCDB simple family (application)
EP 2020078611 W 20201012; AU 2020365314 A 20201012; BR 112022005605 A 20201012; CA 3157823 A 20201012; CL 2022000941 A 20220413; CN 202080072389 A 20201012; CO 2022004464 A 20220407; CR 20220161 A 20201012; EP 20789970 A 20201012; IL 29219422 A 20220412; JO P20220148 A 20201012; JP 2022522986 A 20201012; KR 20227015997 A 20201012; MX 2022004480 A 20201012; PE 2022000593 A 20201012; US 202017769241 A 20201012