EP 4058024 A1 20220921 - METHODS OF TREATING HER2 POSITIVE BREAST CANCER WITH TUCATINIB IN COMBINATION WITH AN ANTI-HER2 ANTIBODY-DRUG CONJUGATE
Title (en)
METHODS OF TREATING HER2 POSITIVE BREAST CANCER WITH TUCATINIB IN COMBINATION WITH AN ANTI-HER2 ANTIBODY-DRUG CONJUGATE
Title (de)
VERFAHREN ZUR BEHANDLUNG VON HER2-POSITIVEM BRUSTKREBS MIT TUCATINIB IN KOMBINATION MIT EINEM ANTI-HER2-ANTIKÖRPER-WIRKSTOFF-KONJUGAT
Title (fr)
MÉTHODES DE TRAITEMENT DU CANCER DU SEIN HER2 POSITIF AVEC DU TUCATINIB EN COMBINAISON AVEC UN CONJUGUÉ MÉDICAMENT-ANTICORPS ANTI-HER2
Publication
Application
Priority
- US 201962935989 P 20191115
- US 201962945321 P 20191209
- US 202063071800 P 20200828
- US 2020060431 W 20201113
Abstract (en)
[origin: WO2021097220A1] The present disclosure relates to a method for treating or ameliorating the effects of a HER2 positive breast cancer in a subject by administration of a combination of tucatinib and an anti-HER2 antibody-drug conjugate (e.g., ado-trastuzumab emtansine or trastuzumab deruxtecan). In some embodiments, the methods provided herein are useful for treating or ameliorating the effects of a brain metastasis in a subject having a HER2 positive breast cancer by administration of a combination of tucatinib and an anti-HER2 antibody-drug conjugate (e.g., ado-trastuzumab emtansine or trastuzumab deruxtecan).
IPC 8 full level
A61K 31/517 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01)
CPC (source: EP IL KR US)
A61K 31/517 (2013.01 - EP IL KR US); A61K 39/39558 (2013.01 - EP IL KR); A61K 45/06 (2013.01 - EP IL KR US); A61K 47/6803 (2017.08 - KR); A61K 47/68033 (2023.08 - EP IL US); A61K 47/68037 (2023.08 - EP IL US); A61K 47/6855 (2017.08 - EP IL KR US); A61P 1/12 (2018.01 - KR); A61P 35/00 (2018.01 - EP IL KR US); A61P 35/04 (2018.01 - US); C07K 16/32 (2013.01 - EP IL KR); A61K 2039/505 (2013.01 - EP IL KR); A61K 2039/545 (2013.01 - EP IL KR); A61K 2300/00 (2013.01 - KR); C07K 2317/77 (2013.01 - EP IL KR)
C-Set (source: EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2021097220 A1 20210520; AU 2020381495 A1 20220519; CA 3159770 A1 20210520; CN 114945369 A 20220826; EP 4058024 A1 20220921; IL 292886 A 20220701; JP 2023502929 A 20230126; KR 20220115566 A 20220817; MX 2022005903 A 20221213; US 2022387618 A1 20221208
DOCDB simple family (application)
US 2020060431 W 20201113; AU 2020381495 A 20201113; CA 3159770 A 20201113; CN 202080087421 A 20201113; EP 20820706 A 20201113; IL 29288622 A 20220509; JP 2022527994 A 20201113; KR 20227020230 A 20201113; MX 2022005903 A 20201113; US 202017775492 A 20201113