EP 4067489 A1 20221005 - METHOD FOR REDUCING TOXICITY OF ANTISENSE NUCLEIC ACIDS
Title (en)
METHOD FOR REDUCING TOXICITY OF ANTISENSE NUCLEIC ACIDS
Title (de)
VERFAHREN ZUR VERMINDERUNG DER TOXIZITÄT VON ANTISENSE-NUKLEINSÄUREN
Title (fr)
MÉTHODE VISANT À RÉDUIRE LA TOXICITÉ D'ACIDES NUCLÉIQUES ANTISESNS
Publication
Application
Priority
- JP 2019214766 A 20191127
- JP 2020044370 W 20201127
Abstract (en)
The purpose of the present invention is to reduce the strong hepatotoxicity of antisense nucleic acids that incorporate an artificial nucleobase (e.g., LNA). The present invention provides a bridged antisense nucleic acid for which antisense nucleic acid-induced toxicity is reduced by the supplemental addition to the wing region of a specific artificial nucleobase (e.g., MCA), while retaining the sequence of the antisense nucleic acid and the number of artificial nucleobases (e.g., LNA). The present invention also provides an antisense nucleic acid drug having a remarkably-reduced hepatotoxicity.
IPC 8 full level
C12N 15/113 (2010.01); A61K 31/7125 (2006.01); A61K 48/00 (2006.01); A61P 43/00 (2006.01); C07H 21/04 (2006.01)
CPC (source: CN EP US)
A61K 31/7125 (2013.01 - CN EP US); A61K 48/00 (2013.01 - EP); A61K 48/005 (2013.01 - CN); A61P 43/00 (2018.01 - CN EP US); C07H 21/04 (2013.01 - CN EP US); C12N 15/113 (2013.01 - CN EP US); C12N 2310/11 (2013.01 - CN EP US); C12N 2310/315 (2013.01 - EP US); C12N 2310/321 (2013.01 - CN EP); C12N 2310/3231 (2013.01 - EP); C12N 2310/341 (2013.01 - EP US); C12N 2320/53 (2013.01 - CN)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
US 2022251557 A1 20220811; CN 114127292 A 20220301; EP 4067489 A1 20221005; EP 4067489 A4 20240612; JP WO2021107143 A1 20210603; WO 2021107143 A1 20210603
DOCDB simple family (application)
US 202017628881 A 20201127; CN 202080052461 A 20201127; EP 20894697 A 20201127; JP 2020044370 W 20201127; JP 2021561576 A 20201127