EP 4073256 A1 20221019 - PRODUCTION OF RECOMBINANT PROTEINS USING FAH AS THE SELECTION MARKER
Title (en)
PRODUCTION OF RECOMBINANT PROTEINS USING FAH AS THE SELECTION MARKER
Title (de)
PRODUKTION REKOMBINANTER PROTEINE MITTELS FAH ALS SELEKTIONSMARKER
Title (fr)
PRODUCTION DE PROTÉINES RECOMBINANTES À L'AIDE DE LA FAH EN TANT QUE MARQUEUR DE SÉLECTION
Publication
Application
Priority
- DE 102019134122 A 20191212
- EP 2020086028 W 20201214
Abstract (en)
[origin: WO2021116495A1] The invention relates to a gene construct, comprising at least two nucleic acid sequences, one of the nucleic acid sequences coding FAH and a second nucleic acid sequence coding a protein to be produced. This makes it possible to use FAH as the selection marker for the production of recombinant proteins, in particular antibodies. The invention further relates to plasmids, vectors or hepatocytes comprising the gene construct. The invention also relates to a method for producing recombinant proteins in FAH(-/-) non-human mammals using the gene constructs and FAH as the selection marker.
IPC 8 full level
C12N 15/63 (2006.01); C12N 15/52 (2006.01)
CPC (source: EP US)
C12N 5/067 (2013.01 - US); C12N 15/52 (2013.01 - EP US); C12N 2015/8518 (2013.01 - US)
Citation (search report)
See references of WO 2021116495A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2021116495 A1 20210617; EP 4073256 A1 20221019; US 2023029363 A1 20230126
DOCDB simple family (application)
EP 2020086028 W 20201214; EP 20838382 A 20201214; US 202017757131 A 20201214