Global Patent Index - EP 4090686 A4

EP 4090686 A4 20240327 - PRO-ANTIBODY THAT REDUCES OFF-TARGET TOXICITY

Title (en)

PRO-ANTIBODY THAT REDUCES OFF-TARGET TOXICITY

Title (de)

PRO-ANTIKÖRPER, DER DIE OFF-TARGET-TOXIZITÄT REDUZIERT

Title (fr)

PRO-ANTICORPS RÉDUISANT LA TOXICITÉ HORS CIBLE

Publication

EP 4090686 A4 20240327 (EN)

Application

EP 21741991 A 20210115

Priority

  • US 202062962555 P 20200117
  • US 2021013688 W 20210115

Abstract (en)

[origin: CN114945597A] The present invention includes proteins, nucleic acids, and methods of making and using activatable antibodies (aAb) comprising, in order: a first light chain comprising a first light chain variable region; a cuttable joint; a first heavy chain comprising a first heavy chain variable region; wherein the cleavable linker prevents or reduces the formation of a first antigen binding site for the first antigen by the first light chain and the first heavy chain; and wherein cleavage of the cleavable linker releases the first heavy chain to effect formation of a first antigen binding site to bind a first antigen.

IPC 8 full level

C07K 16/30 (2006.01); A61P 17/06 (2006.01); A61P 35/00 (2006.01); A61P 37/02 (2006.01); G01N 33/58 (2006.01)

CPC (source: EP)

C07K 16/00 (2013.01); C07K 16/28 (2013.01); C07K 16/2809 (2013.01); C07K 16/2818 (2013.01); C07K 16/30 (2013.01); C07K 16/46 (2013.01); C07K 2317/31 (2013.01); C07K 2317/60 (2013.01); C07K 2317/70 (2013.01); C07K 2319/00 (2013.01); C07K 2319/50 (2013.01)

Citation (search report)

  • [XI] WO 2019051102 A2 20190314 - MAVERICK THERAPEUTICS INC [US]
  • [XI] WO 2017156178 A1 20170914 - MAVERICK THERAPEUTICS INC [US]
  • [XI] LANG SHANSHAN ET AL: "LegoBody: facile generation of bispecific and multi-specific antibodies", BIORXIV, 27 December 2019 (2019-12-27), XP093129094, Retrieved from the Internet <URL:https://www.biorxiv.org/content/10.1101/2019.12.25.888586v1.full.pdf> [retrieved on 20240208], DOI: 10.1101/2019.12.25.888586

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

CN 114945597 A 20220826; EP 4090686 A2 20221123; EP 4090686 A4 20240327

DOCDB simple family (application)

CN 202180009547 A 20210115; EP 21741991 A 20210115