Global Patent Index - EP 4097120 A4

EP 4097120 A4 20240501 - ISOTOPICALLY LABELLED SELECTIVE CXCR4 BINDING PEPTIDE CONJUGATE AND METHODS FOR MAKING AND USING THE SAME

Title (en)

ISOTOPICALLY LABELLED SELECTIVE CXCR4 BINDING PEPTIDE CONJUGATE AND METHODS FOR MAKING AND USING THE SAME

Title (de)

ISOTOPENMARKIERTES SELEKTIVES CXCR4-BINDENDES PEPTIDKONJUGAT UND VERFAHREN ZU DESSEN HERSTELLUNG UND VERWENDUNG

Title (fr)

CONJUGUÉ PEPTIDIQUE DE LIAISON SÉLECTIVE À CXCR4 MARQUÉ PAR ISOTOPE ET SES PROCÉDÉS DE FABRICATION ET D'UTILISATION

Publication

EP 4097120 A4 20240501 (EN)

Application

EP 20915510 A 20200327

Priority

  • US 202016752690 A 20200126
  • US 2020025522 W 20200327

Abstract (en)

[origin: WO2021150258A1] The present invention provides a selective CXCR4 binding peptide conjugate ("PC"), and a method for using and producing the same. In particular, the selective CXCR4 binding peptide conjugate of the invention comprises a peptide portion that selectively binds to CXCR4 and a medically useful compound, such as an imaging agent, a diagnostic agent, or a therapeutically or pharmaceutically active compound. In one particular embodiment, the selective CXCR4 binding peptide conjugate ("PC") is of the formula: (SEQ ID NO:1) or a pharmaceutically acceptable salt thereof, wherein a, b, AA1, AA2, Ar1, X1, and AA3 are those defined herein. The peptide conjugate of the invention can be used in a variety of medical applications including, but not limited to, a targeted drug delivery or imaging a patient or diagnosing a patient for a disease or a clinical condition associated with overexpression and/or upregulation of CXCR4, such as cancers, HIV infection, and immune disorders. Compositions, kits and methods are also disclosed herein for such uses.

IPC 8 full level

A61K 47/64 (2017.01); A61K 51/08 (2006.01); A61P 35/00 (2006.01); C07B 59/00 (2006.01); C07K 5/12 (2006.01); C07K 7/06 (2006.01); C07K 7/50 (2006.01)

CPC (source: EP)

A61K 47/64 (2017.07); A61K 51/08 (2013.01); A61P 35/00 (2017.12); C07B 59/008 (2013.01); C07K 7/06 (2013.01)

Citation (search report)

  • [IY] WO 2019050564 A1 20190314 - MAINLINE BIOSCIENCES [US]
  • [Y] WO 2008150689 A1 20081211 - LILLY CO ELI [US], et al
  • [Y] JENS ATZRODT ET AL: "Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, HOBOKEN, USA, vol. 57, no. 7, 16 August 2017 (2017-08-16), pages 1758 - 1784, XP072090446, ISSN: 1433-7851, DOI: 10.1002/ANIE.201704146
  • [Y] JOSEPH LAU ET AL: "[ 68 Ga]Ga/[ 177 Lu]Lu-BL01, a Novel Theranostic Pair for Targeting C-X-C Chemokine Receptor 4", MOLECULAR PHARMACEUTICS, vol. 16, no. 11, 23 September 2019 (2019-09-23), US, pages 4688 - 4695, XP055748853, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.9b00808
  • [Y] ÅBERG OLA ET AL: "18F-labelling of a cyclic pentapeptide inhibitor of the chemokine receptor CXCR4", JOURNAL OF FLUORINE CHEMISTRY, vol. 135, 28 November 2011 (2011-11-28), pages 200 - 206, XP028897524, ISSN: 0022-1139, DOI: 10.1016/J.JFLUCHEM.2011.11.003
  • See references of WO 2021150258A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2021150258 A1 20210729; WO 2021150258 A9 20211111; CN 115003684 A 20220902; EP 4097120 A1 20221207; EP 4097120 A4 20240501; JP 2023516878 A 20230421

DOCDB simple family (application)

US 2020025522 W 20200327; CN 202080094623 A 20200327; EP 20915510 A 20200327; JP 2022545389 A 20200327