EP 4098651 C0 20240207 - PROCESS FOR THE PREPARATION OF BERAPROST OR SIMILAR BENZOPROSTACYCLIN ANALOGUES STARTING FROM 2-(3-BROMO-2-FLUOROPHENYL)-4-HYDROXYCYCLOPENT-2-ENONE OR SIMILAR REACTANTS
Title (en)
PROCESS FOR THE PREPARATION OF BERAPROST OR SIMILAR BENZOPROSTACYCLIN ANALOGUES STARTING FROM 2-(3-BROMO-2-FLUOROPHENYL)-4-HYDROXYCYCLOPENT-2-ENONE OR SIMILAR REACTANTS
Title (de)
VERFAHREN ZUR HERSTELLUNG VON BERAPROST ODER ÄHNLICHE BENZOPROSTACYCLIN-ANALOGE AUSGEHEND VON 2-(3-BROMO-2-FLUOROPHENYL)-4-HYDROXYCYCLOPENT-2-ENON ODER ÄHNLICHEN REAKTANDEN
Title (fr)
PROCÉDÉ POUR LA PRÉPARATION DE BERAPROST OU ANALOGUES DE BENZOPROSTACYCLIN SIMILAIRES À PARTIR DE 2-(3-BROMO-2-FLUOROPHÉNYL)-4-HYDROXYCYCLOPENT-2-ÉNONE OU RÉACTIFS SIMILAIRES
Publication
Application
Priority
US 202117336865 A 20210602
Abstract (en)
[origin: EP4098651A1] The present invention relates to a process for preparing benzoprostacyclin analogues such as e.g. beraprost (4-((1 RS ,2 RS ,3a SR ,8b SR )-2-hydroxy-1-((3 SR , E )-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)-2,3,3a,8b-tetrahydro-1 H -cyclopenta[ b ]benzofuran-5-yl)butanoic acid)starting from cyclopentenone intermediates e.g. of formula I in racemic or optically enriched formsuch as e.g. 2-(3-bromo-2-fluorophenyl)-4-hydroxycyclopent-2-enoneBeraprost and its enantiomerically pure beraprost-314d stereoisomer are pharmacologically active compounds for the treatment of pulmonary hypertension and vascular diseases.
IPC 8 full level
C07D 307/93 (2006.01); A61K 31/343 (2006.01); A61P 9/08 (2006.01); A61P 9/12 (2006.01); A61P 11/00 (2006.01); C07C 49/537 (2006.01); C07D 307/42 (2006.01); C07C 45/67 (2006.01)
CPC (source: CN EP KR US)
A61P 9/08 (2017.12 - EP); A61P 9/12 (2017.12 - EP); A61P 11/00 (2017.12 - EP); C07C 45/65 (2013.01 - US); C07C 45/676 (2013.01 - EP); C07C 49/573 (2013.01 - US); C07C 49/693 (2013.01 - KR); C07C 49/733 (2013.01 - KR); C07C 49/747 (2013.01 - CN); C07C 67/24 (2013.01 - US); C07C 67/317 (2013.01 - US); C07C 69/157 (2013.01 - CN US); C07C 69/734 (2013.01 - US); C07C 69/757 (2013.01 - KR); C07D 307/42 (2013.01 - EP US); C07D 307/77 (2013.01 - CN); C07D 307/93 (2013.01 - EP KR US); C07D 309/12 (2013.01 - CN); C07F 7/1804 (2013.01 - CN); C07F 7/188 (2013.01 - CN); C07F 7/1892 (2013.01 - US); C12N 9/16 (2013.01 - KR); C12P 7/24 (2013.01 - KR); C12P 7/38 (2013.01 - CN US); C12P 41/004 (2013.01 - CN); C07B 2200/07 (2013.01 - CN); C07C 2601/08 (2017.04 - US); C07C 2601/10 (2017.04 - CN US); C07C 2601/16 (2017.04 - US)
C-Set (source: EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Participating member state (EPC – UP)
AT BE BG DE DK EE FI FR IT LT LU LV MT NL PT SE SI
DOCDB simple family (publication)
EP 4098651 A1 20221207; EP 4098651 B1 20240207; EP 4098651 C0 20240207; CN 115433071 A 20221206; JP 2022185576 A 20221214; KR 20220163276 A 20221209; TW 202248197 A 20221216; US 11884640 B2 20240130; US 2023002339 A1 20230105; US 2023416216 A1 20231228; US 2024150308 A1 20240509
DOCDB simple family (application)
EP 22172492 A 20220510; CN 202210624507 A 20220602; JP 2022085012 A 20220525; KR 20220065298 A 20220527; TW 111120557 A 20220602; US 202117336865 A 20210602; US 202318467441 A 20230914; US 202318532307 A 20231207