EP 4100028 A4 20230726 - COMPOSITIONS AND METHODS FOR TREATING MESOTHELIN POSITIVE CANCERS
Title (en)
COMPOSITIONS AND METHODS FOR TREATING MESOTHELIN POSITIVE CANCERS
Title (de)
ZUSAMMENSETZUNGEN UND VERFAHREN ZUM BEHANDELN VON MESOTHELIN-POSITIVEN KARZINOMEN
Title (fr)
COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE CANCERS POSITIFS À LA MÉSOTHÉLINE
Publication
Application
Priority
- US 202063068245 P 20200820
- US 202063085971 P 20200930
- US 2021046751 W 20210819
Abstract (en)
[origin: WO2022040454A1] The disclosure provides immune cells comprising a first activator receptor specific to mesothelin and a second inhibitory receptor specific to a ligand that has been lost in a mesothelin-positive cancer cell, and methods of making and using same for the treatment of cancer.
IPC 8 full level
C07K 14/705 (2006.01); A61K 35/17 (2015.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C07K 14/74 (2006.01); C12N 5/0783 (2010.01)
CPC (source: EP IL KR US)
A61K 35/17 (2013.01 - US); A61K 38/00 (2013.01 - IL); A61K 39/4611 (2023.05 - EP IL KR); A61K 39/4631 (2023.05 - EP IL KR); A61K 39/4632 (2023.05 - EP IL KR); A61K 39/464468 (2023.05 - EP IL KR); A61P 35/00 (2018.01 - EP IL KR US); C07K 14/705 (2013.01 - EP IL); C07K 14/7051 (2013.01 - IL KR US); C07K 14/70539 (2013.01 - EP IL KR); C12N 5/0636 (2013.01 - EP IL KR); C12N 15/1138 (2013.01 - IL US); A61K 38/00 (2013.01 - US); A61K 2039/5158 (2013.01 - KR); C07K 2317/622 (2013.01 - IL KR US); C07K 2319/03 (2013.01 - IL KR US); C12N 2310/531 (2013.01 - IL US); C12N 2501/2302 (2013.01 - EP IL); C12N 2501/2315 (2013.01 - EP IL); C12N 2501/2321 (2013.01 - EP IL); C12N 2502/30 (2013.01 - EP IL); C12N 2510/00 (2013.01 - EP IL KR)
Citation (search report)
- [I] WO 2020065406 A2 20200402 - IMMPACT BIO LTD [IL], et al
- [I] WO 2019068007 A1 20190404 - IMMPACT BIO LTD [IL], et al
- [A] WO 2015090230 A1 20150625 - NOVARTIS AG [CH], et al
- [A] V. D. FEDOROV ET AL: "PD-1- and CTLA-4-Based Inhibitory Chimeric Antigen Receptors (iCARs) Divert Off-Target Immunotherapy Responses", SCIENCE TRANSLATIONAL MEDICINE, vol. 5, no. 215, 11 December 2013 (2013-12-11), pages 215ra172 - 215ra172, XP055210508, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.3006597
- [A] RAFIQ SARWISH ET AL: "Engineering strategies to overcome the current roadblocks in CAR T cell therapy", NATURE REVIEWS CLINICAL ONCOLOGY, NATURE, NY, US, vol. 17, no. 3, 17 December 2019 (2019-12-17), pages 147 - 167, XP037114979, ISSN: 1759-4774, [retrieved on 20191217], DOI: 10.1038/S41571-019-0297-Y
- See also references of WO 2022040454A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2022040454 A1 20220224; AU 2021329371 A1 20230420; CA 3188862 A1 20220224; EP 4100028 A1 20221214; EP 4100028 A4 20230726; IL 300500 A 20230401; JP 2023538114 A 20230906; KR 20230051677 A 20230418; MX 2023002041 A 20230427; US 11602543 B2 20230314; US 2022370497 A1 20221124; US 2023277590 A1 20230907
DOCDB simple family (application)
US 2021046751 W 20210819; AU 2021329371 A 20210819; CA 3188862 A 20210819; EP 21859151 A 20210819; IL 30050023 A 20230208; JP 2023512376 A 20210819; KR 20237007037 A 20210819; MX 2023002041 A 20210819; US 202217662766 A 20220510; US 202218062873 A 20221207