Global Patent Index - EP 4108289 A1

EP 4108289 A1 20221228 - DEVICES AND SYSTEMS FOR ELECTRICAL STIMULATION AND METHODS OF USE

Title (en)

DEVICES AND SYSTEMS FOR ELECTRICAL STIMULATION AND METHODS OF USE

Title (de)

VORRICHTUNGEN UND SYSTEME FÜR ELEKTRISCHE STIMULATION UND VERFAHREN ZUR VERWENDUNG

Title (fr)

DISPOSITIFS ET SYSTÈMES DE STIMULATION ÉLECTRIQUE ET PROCÉDÉS D'UTILISATION

Publication

EP 4108289 A1 20221228 (EN)

Application

EP 21181877 A 20210625

Priority

US 202117357836 A 20210624

Abstract (en)

The present disclosure provides devices, systems, and methods for spinal cord stimulation. In some exemplary embodiments, a lead is provided. In one exemplary embodiment, the lead includes a paddle and an electrode array distributed in the paddle. The electrode array includes a first column of electrodes and a second column of electrodes. The first column of electrodes and the second column of electrodes are symmetric about the midline of the paddle. The first column of electrodes includes a first electrode, a second electrode, and a third electrode. The second column of electrodes includes a fourth electrode corresponding to the first electrode, a fifth electrode corresponding to the second electrode, and a sixth electrode corresponding to the third electrode. A vertical inter-electrode distance between the first electrode and the second electrode is larger than that between the second electrode and the third electrode.

IPC 8 full level

A61N 1/05 (2006.01)

CPC (source: CN EP US)

A61N 1/0553 (2013.01 - EP US); A61N 1/36062 (2017.08 - CN US); H01B 5/14 (2013.01 - US); A61N 1/36062 (2017.08 - EP)

Citation (applicant)

  • CAPOGROSSO M ET AL.: "A Computational Model for Epidural Electrical Stimulation of Spinal Sensorimotor Circuits", JOURNAL O/NEUROSCIENCE, vol. 33, 4 December 2013 (2013-12-04), pages 49
  • WENGER N ET AL.: "Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury", SCIENCE TRANSLATIONAL MEDICINE, vol. 6, 24 September 2014 (2014-09-24), pages 255, XP055410746, DOI: 10.1126/scitranslmed.3008325
  • LU DC ET AL.: "Engaging Cervical Spinal Cord Networks to Reenable Volitional Control of Hand Function in Tetraplegic Patients", NEUROREHABILITATION AND NEURAL REPAIR, vol. 30, no. 10, November 2016 (2016-11-01), pages 951 - 962
  • CHANDRASEKARAN ET AL.: "Sensory restoration by epidural stimulation of the lateral spinal cord in upper-limb amputees", ELIFE, vol. 9, July 2020 (2020-07-01), pages e54349
  • SCHIRMER ET AL.: "Heuristic map of myotomal innervation in humans using direct intraoperative nerve root stimulation", JOURNAL OF NEUROSURGERY: SPINE SPI, vol. 15, no. 1, July 2011 (2011-07-01), pages 64 - 70
  • KO ET AL.: "Gross quantitative measurements of spinal cord segments in human", SPINAL CORD, vol. 42, 2004, pages 35 - 40
  • FROSTELL: "A Review of the Segmental Diameter of the Healthy Human Spinal Cord", FRONT NEUROL., vol. 7, December 2016 (2016-12-01), pages 238
  • MENDEZ: "Segment-Specific Orientation of the Dorsal and Ventral Roots for Precise Therapeutic Targeting of Human Spinal Cord", MAYO CLIN PROC, vol. 96, no. 6, June 2021 (2021-06-01), pages 1426 - 1437
  • SQUAIR ET AL.: "Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury", NATURE, vol. 590, 2021, pages 308 - 314, XP037366163, DOI: 10.1038/s41586-020-03180-w
  • LANG ET AL.: "Uber den lumbosakralen Teil des Duralsackes und die Topographie seines", INHALTS,MORPHOL. MED., vol. 3, 1983, pages 2746
  • TOOSSI ET AL.: "Comparative neuroanatomy of the lumbosacral spinal cord of the rat, cat, pig, monkey, and human", SCI REP, vol. 11, 2021, pages 1955
  • ZHOU ET AL.: "Microsurgical anatomy of lumbosacral nerve rootlets for highly selective rhizotomy in chronic spinal cord injury", THE ANATOMICAL RECORD, vol. 293, 2010, pages 2123 - 2128
  • D'AVELLA ET AL.: "Microsurgical anatomy of lumbosacral spinal roots", J NEUROSURG, vol. 51, no. 6, December 1979 (1979-12-01), pages 819 - 23
  • MAMATHA ET AL.: "Morphology of nerve rootlets and spinal segments in the lumbosacral region: An anatomical study", RESEARCH JOURNAL OF PHARMACEUTICAL, BIOLOGICAL AND CHEMICAL SCIENCES, vol. 7, no. 1, 2016, pages 1848 - 1854

Citation (search report)

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

Designated validation state (EPC)

KH MA MD TN

DOCDB simple family (publication)

EP 4108289 A1 20221228; CN 115518290 A 20221227; US 11911621 B2 20240227; US 2022409899 A1 20221229

DOCDB simple family (application)

EP 21181877 A 20210625; CN 202210719257 A 20220623; US 202117357836 A 20210624