EP 4110780 A4 20230705 - 1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
Title (en)
1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
Title (de)
1,3,4OXADIAZOLDERIVATVERBINDUNGEN ALS HISTONDEACETYLASE-6-HEMMER UND PHARMAZEUTISCHE ZUSAMMENSETZUNG DAMIT
Title (fr)
COMPOSÉS DÉRIVÉS DE 1,3,4-OXADIAZOLE UTILISÉS COMME INHIBITEURS D'HISTONE DÉSACÉTYLASE 6, ET COMPOSITION PHARMACEUTIQUE LES COMPRENANT
Publication
Application
Priority
- KR 20200023249 A 20200225
- KR 2021002362 W 20210225
Abstract (en)
[origin: WO2021172886A1] The present invention relates to a novel compound having a histone deacetylase 6 (HDAC6) inhibitory activity, an isomer thereof or a pharmaceutically acceptable salt thereof, the use thereof for preparing a therapeutic medicament; a pharmaceutical composition containing the same, and a treatment method using the composition; and a preparation method thereof. The novel compound, the isomer thereof, or the pharmaceutically acceptable salt thereof according to the present invention has the HDAC6 inhibitory activity, which is effective in the prevention or treatment of HDAC6-mediated diseases including cancer, inflammatory diseases, autoimmune diseases, neurological or neurodegenerative diseases.
IPC 8 full level
C07D 471/04 (2006.01); A61K 31/4545 (2006.01); A61K 31/496 (2006.01); A61P 25/00 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01)
CPC (source: EP KR US)
A61K 31/4545 (2013.01 - KR); A61K 31/496 (2013.01 - KR); A61P 25/00 (2018.01 - EP KR); A61P 29/00 (2018.01 - EP KR); A61P 35/00 (2018.01 - EP KR); A61P 37/00 (2018.01 - EP KR); C07D 471/04 (2013.01 - EP KR US); C07D 519/00 (2013.01 - EP US)
Citation (search report)
- [A] WO 2017222950 A1 20171228 - MERCK SHARP & DOHME [US], et al
- [A] WO 2017030938 A1 20170223 - INCYTE CORP [US]
- [A] WO 2009002534 A1 20081231 - GILEAD COLORADO INC [US], et al
- See also references of WO 2021172886A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2021172886 A1 20210902; AU 2021225683 A1 20220901; AU 2021225683 B2 20231207; BR 112022016743 A2 20221018; CA 3167361 A1 20210902; CN 115151542 A 20221004; EP 4110780 A1 20230104; EP 4110780 A4 20230705; EP 4110780 B1 20240807; JP 2023516824 A 20230420; JP 7525662 B2 20240730; KR 102537616 B1 20230526; KR 20210108274 A 20210902; MX 2022010394 A 20220907; TW 202146408 A 20211216; TW I786553 B 20221211; US 2023147859 A1 20230511
DOCDB simple family (application)
KR 2021002362 W 20210225; AU 2021225683 A 20210225; BR 112022016743 A 20210225; CA 3167361 A 20210225; CN 202180016680 A 20210225; EP 21760387 A 20210225; JP 2022576784 A 20210225; KR 20200023249 A 20200225; MX 2022010394 A 20210225; TW 110106772 A 20210225; US 202117904806 A 20210225