EP 4110801 A1 20230104 - CHIMERIC RECEPTORS FOR USE IN ENGINEERED CELLS
Title (en)
CHIMERIC RECEPTORS FOR USE IN ENGINEERED CELLS
Title (de)
CHIMÄRE REZEPTOREN ZUR VERWENDUNG IN MANIPULIERTEN ZELLEN
Title (fr)
RÉCEPTEURS CHIMÉRIQUES DESTINÉS À ÊTRE UTILISÉS DANS DES CELLULES MODIFIÉES
Publication
Application
Priority
- GB 202002622 A 20200225
- GB 202002620 A 20200225
- EP 2021054578 W 20210224
Abstract (en)
[origin: WO2021170666A1] The present invention provides a nucleic acid molecule comprising a polynucleotide sequence encoding a chimeric receptor, particularly a chimeric antigen receptor (CAR), wherein said chimeric receptor comprises an endodomain comprising (i) a STAT5 association motif, and a JAK1 and/or JAK2 binding motif and (ii) a JAK3 binding motif, wherein (i) and (ii) are connected by a linker or hinge.
IPC 8 full level
C07K 14/705 (2006.01); A61K 39/00 (2006.01); C07K 14/715 (2006.01); C07K 14/725 (2006.01); C12N 9/12 (2006.01)
CPC (source: EP GB US)
A61K 39/4611 (2023.05 - EP GB); A61K 39/4621 (2023.05 - EP GB); A61K 39/4631 (2023.05 - EP GB); A61K 39/4644 (2023.05 - EP GB); A61K 39/464419 (2023.05 - EP GB); C07K 14/705 (2013.01 - EP GB); C07K 14/7051 (2013.01 - EP GB US); C07K 14/70521 (2013.01 - EP GB US); A61K 2039/5156 (2013.01 - US); C07K 14/7155 (2013.01 - EP GB US); C07K 2319/03 (2013.01 - EP GB US); C12N 9/12 (2013.01 - EP GB US); C12Y 207/10002 (2013.01 - EP GB US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2021170666 A1 20210902; CN 115427440 A 20221202; EP 4110801 A1 20230104; GB 202213861 D0 20221109; GB 2609103 A 20230125; TW 202146431 A 20211216; US 2023138428 A1 20230504
DOCDB simple family (application)
EP 2021054578 W 20210224; CN 202180024453 A 20210224; EP 21708195 A 20210224; GB 202213861 A 20210224; TW 110106561 A 20210224; US 202117802018 A 20210224