EP 4111208 A4 20240410 - A SYSTEM FOR REAL-TIME MONITORING OF PROTEIN AND EXCIPIENTS
Title (en)
A SYSTEM FOR REAL-TIME MONITORING OF PROTEIN AND EXCIPIENTS
Title (de)
SYSTEM ZUR ECHTZEITÜBERWACHUNG VON PROTEIN UND HILFSSTOFFEN
Title (fr)
SYSTÈME DE SURVEILLANCE EN TEMPS RÉEL D'UNE PROTÉINE ET D'EXCIPIENTS
Publication
Application
Priority
- IN 202011007820 A 20200224
- IN 2021050176 W 20210224
Abstract (en)
[origin: WO2021171310A1] In an example, a system (100) for real-time monitoring of a protein and excipients during formulation of drugs with monoclonal antibodies, comprises a first reservoir (102) with a solution with the protein and the excipients; a first pump (104) coupled to the first reservoir (102) to pass from through a membrane; a first pressure transmitter (108) coupled to an output from the membrane to direct a retentate solution to the first reservoir (102); a second reservoir (110) with a diafiltration buffer solution; a second pump (112) coupled to the second reservoir (110) to pump the diafiltration buffer solution from the second reservoir (110) into the first reservoir (102); and a spectroscopic probe (114) dipped in the first reservoir (102) to continuously acquire the wavelength spectra to monitor the formulation of the protein and the excipients during the formulation.
IPC 8 full level
G01N 21/359 (2014.01); G01N 21/3577 (2014.01); G01N 21/85 (2006.01)
CPC (source: EP)
G01N 21/3577 (2013.01); G01N 21/359 (2013.01); G01N 21/8507 (2013.01); G01N 21/05 (2013.01); G01N 21/552 (2013.01); G01N 2021/3595 (2013.01); G01N 2021/8411 (2013.01); G01N 2021/8528 (2013.01); G01N 2201/129 (2013.01)
Citation (search report)
- [XYI] US 2012123688 A1 20120517 - RAMASUBRAMANYAN NATARAJAN [US], et al
- [XY] WO 2017174580 A1 20171012 - BOEHRINGER INGELHEIM RCV GMBH [AT], et al
- [Y] WO 2020016417 A1 20200123 - ICHNOS SCIENCES S A [CH]
- [Y] WO 2017051273 A1 20170330 - PFIZER [US]
- [Y] US 2002155541 A1 20021024 - NAUGHTON RAYMOND A [US], et al
- [Y] ANIRUDH M K NAMBIAR ET AL: "Countercurrent staged diafiltration for formulation of high value proteins", BIOTECHNOLOGY AND BIOENGINEERING, JOHN WILEY, HOBOKEN, USA, vol. 115, no. 1, 6 October 2017 (2017-10-06), pages 139 - 144, XP071153567, ISSN: 0006-3592, DOI: 10.1002/BIT.26441
- See also references of WO 2021171310A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2021171310 A1 20210902; EP 4111208 A1 20230104; EP 4111208 A4 20240410
DOCDB simple family (application)
IN 2021050176 W 20210224; EP 21760637 A 20210224