Global Patent Index - EP 4112733 A4

EP 4112733 A4 20230906 - METHOD FOR SYNTHESIZING CHIRAL DIAMINE COMPOUND

Title (en)

METHOD FOR SYNTHESIZING CHIRAL DIAMINE COMPOUND

Title (de)

VERFAHREN ZUM SYNTHETHISIEREN EINER CHIRALEN DIAMINVERBINDUNG

Title (fr)

PROCÉDÉ DE SYNTHÈSE D'UN COMPOSÉ DE DIAMINE CHIRALE

Publication

EP 4112733 A4 20230906 (EN)

Application

EP 20921866 A 20200331

Priority

  • CN 202010118060 A 20200226
  • CN 2020082594 W 20200331

Abstract (en)

[origin: EP4112733A1] Provided is a method for synthesizing a chiral diamine compound. The synthesizing method includes: converting a substrate represented by Formula I into a chiral diamine compound in Formula I by using a transaminase, herein n=1~10, an R group represents an alkyl, a cycloalkyl, a heteroatom-containing alkyl, a heteroatom-containing cycloalkyl, a heteroatom-containing aryl, an amide compound residue, or an ether compound residue, and a hetero atom is at least one from among O, S and N; R1 and R2 are the same or not the same, the R1 and R2 are respectively and independently hydrogen, a C1-C3 alkyl, or an amino protecting group; and the transaminases are derived from a plurality of strains.The transaminases all have a relatively high reaction selectivity and activity on various substrates represented by Formula 1. By catalyzing and synthesizing a chiral diamine compound by using the biological enzyme, not only is the substrate scope wider, but the route also short and product yield high, thus greatly reducing production costs and reducing the production of an organic solvent and the three wastes.

IPC 8 full level

C12P 13/00 (2006.01); C12N 9/10 (2006.01); C12P 13/02 (2006.01); C12P 17/04 (2006.01); C12P 17/12 (2006.01); C12P 41/00 (2006.01)

CPC (source: CN EP KR US)

C12N 9/1096 (2013.01 - KR); C12P 13/001 (2013.01 - CN EP KR US); C12P 13/02 (2013.01 - EP); C12P 17/04 (2013.01 - CN EP KR US); C12P 17/12 (2013.01 - CN EP KR US); C12P 41/006 (2013.01 - EP); C12Y 206/01 (2013.01 - KR); C12Y 206/01 (2013.01 - EP US); Y02P 20/55 (2015.11 - EP)

Citation (search report)

  • [Y] CN 110616236 A 20191227 - JIMING PHARMATECH SUZHOU LTD
  • [Y] CN 108048419 A 20180518 - ASYMCHEM LIFE SCIENCE TIANJIN CO LTD
  • [Y] CN 110592042 A 20191220 - ASYMCHEM LAB TIANJIN CO LTD
  • [A] TANIZAWA K. ET AL: "Thermostable D-Amino Acid Aminotransferase from a Thermophilic Bacillus Species - Purification, characterisation, and active site sequence determination", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 264, no. 5, 5 February 1989 (1989-02-05), pages 2445 - 2449, XP009095005, ISSN: 0021-9258, DOI: 10.1016/S0021-9258(19)81633-2
  • [A] CHEN Y. ET AL: "Identification of novel thermostable taurine-pyruvate transaminase from Geobacillus thermodenitrificans for chiral amine synthesis", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 100, no. 7, 18 November 2015 (2015-11-18), pages 3101 - 3111, XP035750282, ISSN: 0175-7598, [retrieved on 20151118], DOI: 10.1007/S00253-015-7129-5
  • [A] JOHANN H SATTLER ET AL: "Redox Self-Sufficient Biocatalyst Network for the Amination of Primary Alcohols", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, HOBOKEN, USA, vol. 51, no. 36, 9 August 2012 (2012-08-09), pages 9156 - 9159, XP072073648, ISSN: 1433-7851, DOI: 10.1002/ANIE.201204683
  • [A] GOMM A. ET AL: "Transaminases for chiral amine synthesis", CURRENT OPINION IN CHEMICAL BIOLOGY, CURRENT BIOLOGY LTD, LONDON, GB, vol. 43, 4 January 2018 (2018-01-04), pages 106 - 112, XP085358776, ISSN: 1367-5931, DOI: 10.1016/J.CBPA.2017.12.007
  • [A] KELLY S. A. ET AL: "Application of [omega]-Transaminases in the Pharmaceutical Industry", CHEMICAL REVIEWS, vol. 118, no. 1, 18 December 2017 (2017-12-18), US, pages 349 - 367, XP093058966, ISSN: 0009-2665, DOI: 10.1021/acs.chemrev.7b00437
  • See also references of WO 2021168987A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

EP 4112733 A1 20230104; EP 4112733 A4 20230906; CN 110982856 A 20200410; CN 110982856 B 20200623; JP 2023514862 A 20230411; JP 7345070 B2 20230914; KR 20220157981 A 20221129; US 2023151396 A1 20230518; WO 2021168987 A1 20210902

DOCDB simple family (application)

EP 20921866 A 20200331; CN 2020082594 W 20200331; CN 202010118060 A 20200226; JP 2022551243 A 20200331; KR 20227033472 A 20200331; US 202017905092 A 20200331