Global Patent Index - EP 4129308 A1

EP 4129308 A1 20230208 - TRIPLE TRANSGENIC PIGS SUITABLE FOR XENOGRAFT

Title (en)

TRIPLE TRANSGENIC PIGS SUITABLE FOR XENOGRAFT

Title (de)

FÜR XENOTRANSPLANTAT GEEIGNETE, DREIFACH TRANSGENE SCHWEINE

Title (fr)

PORCS TRIPLES TRANSGÉNIQUES APPROPRIÉS POUR LA XÉNOGREFFE

Publication

EP 4129308 A1 20230208 (EN)

Application

EP 22155977 A 20151021

Previously filed application

PCT/US2015/056730 20151021 WO

Priority

  • US 201462067129 P 20141022
  • EP 15852175 A 20151021
  • US 2015056730 W 20151021

Abstract (en)

The application provides methods of improving a rejection related symptom, reducing premature separation and methods of producing a compound of interest with an altered epitope profile are provided. Knockout pigs with a disrupted gene or genes, and porcine organs, tissues, and cells therefrom are provided.

IPC 8 full level

A61K 35/12 (2006.01); A01K 67/027 (2006.01); A61K 35/22 (2006.01); A61K 35/407 (2006.01); A61P 17/02 (2006.01); A61P 43/00 (2006.01)

CPC (source: EP KR US)

A01K 67/0276 (2013.01 - EP KR US); A61K 35/12 (2013.01 - EP KR US); A61K 35/22 (2013.01 - US); A61K 35/407 (2013.01 - EP KR US); A61P 17/02 (2018.01 - EP); A61P 43/00 (2018.01 - EP); A01K 2217/075 (2013.01 - EP KR US); A01K 2217/15 (2013.01 - EP KR US); A01K 2227/108 (2013.01 - EP KR US); A01K 2267/025 (2013.01 - EP KR US); C12N 2517/02 (2013.01 - EP KR US)

Citation (applicant)

  • US 7795493 B2 20100914 - PHELPS CAROL J [US], et al
  • US 7547816 B2 20090616 - DAY BILLY N [US], et al
  • US 7560538 B2 20090714 - KOIKE CHIHIRO [US]
  • US 7166378 B2 20070123 - HALLUM RYAN [US], et al
  • US 8034330 B2 20111011 - ZHU ALEX [US]
  • US 6166288 A 20001226 - DIAMOND LISA E [US], et al
  • US 6572867 B1 20030603 - SCHWARZ ALEXANDER [US], et al
  • DEMETRIS ET AL.: "Antibody-mediated Rejection of Human Orthotopic Liver Allografts. A study of liver transplantation across ABO blood group barriers", AM J. PATHOL, vol. 132, 1998, pages 489 - 502
  • NAKAMURA ET AL.: "Liver allograft rejection in sensitized recipients. Observations in a Clinically Relevant Small Animal Model", AM J. PATHOL., vol. 142, 1993, pages 1383 - 91
  • FURUYA ET AL.: "Preformed Lymphocytotoxic Antibodies: the Effects of Class, Titer and Specificity on Liver v Heart Allografts", HEPATOLOGY, vol. 16, 1992, pages 1415 - 22
  • TECTOR ET AL.: "Rejection of Pig Liver Xenografts in Patients with Liver Failure: Implications for Xenotransplantation", LIVER TRANSPL, 2001, pages 82 - 9
  • EKSER ET AL.: "Genetically Engineered Pig to Baboon Liver Xenotransplantation: Histopathology of Xenografts and Native Organs", PLOS ONE, 2012, pages e29720
  • KNOSALLA ET AL.: "Renal and Cardia Endothelial Heterogeneity Impact Acute Vascular Rejection in Pig to Baboon Xenotransplantation", AM J TRANSPLANT, 2009, pages 1006 - 16
  • SHIMIZU ET AL.: "Pathologic Characteristics of Transplanted Kidney Xenografts", J. AM. SOC. NEPHROLOGY, 2012, pages 225 - 35
  • MORTON ET AL., VOX SANG, vol. 19, 1970, pages 472 - 482
  • BLANCHARD ET AL., JBC, vol. 258, 1983, pages 7691 - 7685
  • CHEN ET AL., NATURE MED, vol. 11, no. 12, 2005, pages 1295 - 1298
  • BASNET ET AL., XENOTRANSPLANTATION, vol. 17, no. 6, 2010, pages 397 - 410
  • MOHIUDDEN ET AL., AM J. TRANSPLANTATION, vol. 14, 2014, pages 488 - 489
  • MOHIUDDEN ET AL., XENOTRANSPLANTATION, vol. 21, 2014, pages 35 - 45
  • DALL'OLIO ET AL., BIOCHEMICA BIOPHYSICA ACTA, vol. 1840, 2014, pages 443 - 453
  • GHADERI ET AL., NATURE BIOTECHNOLOGY, vol. 28, no. 8, 2010, pages 863 - 867
  • COLIGAN ET AL.: "Current Protocols in Molecular Biology", 2013, WILEY-INTERSCIENCE
  • "Culture of Animal Cells: a manual of basic techniques", vol. 1, 1998, COLD SPRING HARBOR LABORATORY PRESS
  • MATOU-KOVD ET AL., ANN MED BURN CLUB, vol. 7, 1994, pages 143
  • POND W.GHOUPT K.A: "The Biology of the Pig", 1978, COMSTOCK PUB. ASSOCIATES
  • JANDL, J. H: "Blood: Textbook of Hematology", 1996, BROWN
  • MARCUS, D.M.CASS, L.E., SCIENCE, vol. 164, 1969, pages 553 - 555
  • VILLARROYA H ET AL., AUTOIMMUNITY, vol. 6, 1990, pages 47 - 60
  • DIAZ ET AL., TRANSPLANT IMMUNOLOGY, vol. 13, no. 4, 2004, pages 313 - 317

Citation (search report)

  • [XY] WO 2014066505 A1 20140501 - UNIV INDIANA RES & TECH CORP [US], et al
  • [Y] US 2013111614 A1 20130502 - MCGREGOR CHRISTOPHER G A [US], et al
  • [Y] GUERARD W. BYRNE ET AL: "Identification of New Carbohydrate and Membrane Protein Antigens in Cardiac Xenotransplantation :", TRANSPLANTATION, vol. 91, no. 3, February 2011 (2011-02-01), GB, pages 287 - 292, XP055481327, ISSN: 0041-1337, DOI: 10.1097/TP.0b013e318203c27d
  • [Y] GUERARD W. BYRNE ET AL: "Cloning and expression of porcine [beta]1,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen", XENOTRANSPLANTATION, vol. 21, no. 6, September 2014 (2014-09-01), US, pages 543 - 554, XP055481364, ISSN: 0908-665X, DOI: 10.1111/xen.12124

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2016065046 A1 20160428; WO 2016065046 A9 20170629; BR 112017008251 A2 20180502; BR 112017008251 B1 20220222; CA 2965550 A1 20160428; CN 107106607 A 20170829; CN 116059250 A 20230505; EP 3220925 A1 20170927; EP 3220925 A4 20180718; EP 3220925 B1 20220316; EP 4129308 A1 20230208; JP 2017536814 A 20171214; JP 2021045134 A 20210325; JP 2023109993 A 20230808; KR 102659529 B1 20240423; KR 20170074941 A 20170630; KR 20240055155 A 20240426; US 2017311579 A1 20171102

DOCDB simple family (application)

US 2015056730 W 20151021; BR 112017008251 A 20151021; CA 2965550 A 20151021; CN 201580063412 A 20151021; CN 202211157151 A 20151021; EP 15852175 A 20151021; EP 22155977 A 20151021; JP 2017521985 A 20151021; JP 2020186477 A 20201109; JP 2023089398 A 20230531; KR 20177013717 A 20151021; KR 20247012572 A 20151021; US 201515520633 A 20151021