EP 4130033 A1 20230208 - EPITOPE REGION-BRIDGING BIPARATOPIC ANTIBODY AND METHOD FOR PRODUCING SAME
Title (en)
EPITOPE REGION-BRIDGING BIPARATOPIC ANTIBODY AND METHOD FOR PRODUCING SAME
Title (de)
EPITOPREGION-ÜBERBRÜCKENDER BIPARATOPISCHER ANTIKÖRPER UND VERFAHREN ZUR HERSTELLUNG DAVON
Title (fr)
ANTICORPS BIPARATOPIQUE DE PONTAGE DE RÉGION D'ÉPITOPE ET SON PROCÉDÉ DE PRODUCTION
Publication
Application
Priority
- JP 2020061014 A 20200330
- JP 2021013341 W 20210329
Abstract (en)
The present disclosure provides a technique for designing an epitope region-bridging biparatopic antibody, and also provides, through this technique, an antibody that has an improved agonist or antagonist function for an antigen or that promotes or enhances a chemical reaction catalyzed by an enzyme serving as an antigen. Provided is an epitope region-bridging biparatopic antibody, an antigen-binding fragment thereof or a functional equivalent of the same that has antigen specificities to a first epitope belonging to a first epitope group, among a plurality of epitope region groups in an antigen, and to a second epitope belonging to a second epitope group contained in an epitope region different from the epitope region in which the first epitope group is contained, said antibody comprising the sequences of a heavy chain variable region and a light chain variable region derived from an antibody against the first epitope and the sequences of a heavy chain variable region and a light chain variable region derived from an antibody against the second epitope.
IPC 8 full level
C07K 16/00 (2006.01); C07K 16/28 (2006.01); C07K 16/46 (2006.01); C12N 15/13 (2006.01); C40B 40/10 (2006.01)
CPC (source: EP US)
C07K 16/2878 (2013.01 - EP US); C12N 15/1086 (2013.01 - US); A61K 2039/505 (2013.01 - US); C07K 2317/24 (2013.01 - EP); C07K 2317/31 (2013.01 - EP US); C07K 2317/55 (2013.01 - US); C07K 2317/565 (2013.01 - US); C07K 2317/75 (2013.01 - EP); C07K 2317/76 (2013.01 - EP US); C07K 2317/77 (2013.01 - US); C07K 2317/92 (2013.01 - EP US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
EP 4130033 A1 20230208; CN 115380051 A 20221122; JP 2022107633 A 20220722; JP 7101433 B2 20220715; JP WO2021200840 A1 20211007; US 2023192877 A1 20230622; WO 2021200840 A1 20211007
DOCDB simple family (application)
EP 21781490 A 20210329; CN 202180026766 A 20210329; JP 2021013341 W 20210329; JP 2021552206 A 20210329; JP 2022077664 A 20220510; US 202117915837 A 20210329