EP 4132909 A1 20230215 - ORGANIC ACID ADDITION SALTS OF S-PINDOLOL
Title (en)
ORGANIC ACID ADDITION SALTS OF S-PINDOLOL
Title (de)
ORGANISCHE SÄUREADDITIONSSALZE VON S-PINDOLOL
Title (fr)
SELS D'ADDITION D'ACIDE ORGANIQUE DE S-PINDOLOL
Publication
Application
Priority
- GB 202005112 A 20200407
- GB 2021050799 W 20210331
Abstract (en)
[origin: GB2593902A] A pharmaceutically acceptable acid addition salt of: (i) S-pindolol; and (ii) an organic acid, wherein the organic acid has a pKa1 of greater than or equal to 2.5; and a chemical formula of CxHy (CO2H)z, where X is 1 to 10, y is 2 to 20 and z is 1 or 2, is provided. The organic acid may be benzoic acid, succinic acid, fumaric acid, malonic acid, glutaric acid, adipic acid, acetic acid, propionic acid, phenylacetic acid, toluic acid or naphthoic acid. The salt may be S-pindolol benzoate or S-pindolol succinate. A pharmaceutical composition comprising (i) the pharmaceutically acceptable acid addition salt and (ii) a pharmaceutically acceptable excipient, carrier or diluent is provided. The pharmaceutically acceptable acid addition salt for use in the treatment or prevention of a disease or condition selected from cachexia, sarcopenia, a neuromuscular disorder, muscle weakness, hypertension, heart failure, atrial fibrillation, heart attack, angina pectoris, glaucoma and anxiety is provided.
IPC 8 full level
C07D 209/32 (2006.01); A61K 31/405 (2006.01); A61P 9/10 (2006.01); A61P 9/12 (2006.01); A61P 21/00 (2006.01); A61P 25/22 (2006.01); A61P 27/06 (2006.01)
CPC (source: EP GB IL KR US)
A61K 9/20 (2013.01 - IL); A61K 31/19 (2013.01 - GB); A61K 31/192 (2013.01 - GB US); A61K 31/194 (2013.01 - GB US); A61K 31/404 (2013.01 - EP GB IL KR US); A61P 9/04 (2018.01 - GB); A61P 9/10 (2018.01 - EP GB IL); A61P 9/12 (2018.01 - EP GB IL); A61P 19/00 (2018.01 - GB); A61P 21/00 (2018.01 - EP GB IL KR); A61P 25/00 (2018.01 - KR); A61P 25/22 (2018.01 - EP GB IL); A61P 27/06 (2018.01 - EP GB IL); C07C 53/10 (2013.01 - GB); C07C 53/122 (2013.01 - GB); C07C 55/08 (2013.01 - GB); C07C 55/10 (2013.01 - GB); C07C 55/12 (2013.01 - GB); C07C 55/14 (2013.01 - GB); C07C 57/15 (2013.01 - GB); C07C 57/32 (2013.01 - GB); C07C 63/04 (2013.01 - GB); C07C 63/08 (2013.01 - GB); C07C 63/36 (2013.01 - GB); C07D 209/32 (2013.01 - EP IL KR); C07D 209/43 (2013.01 - GB); A61K 9/20 (2013.01 - EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
GB 202005112 D0 20200520; GB 2593902 A 20211013; GB 2593902 B 20220413; AU 2021253747 A1 20221110; BR 112022020198 A2 20221122; CA 3173878 A1 20211014; CN 115916751 A 20230404; DK 4132909 T3 20240513; EP 4132909 A1 20230215; EP 4132909 B1 20240410; EP 4385566 A2 20240619; EP 4385566 A3 20240918; ES 2982095 T3 20241014; FI 4132909 T3 20240523; HR P20240922 T1 20241011; IL 297045 A 20221201; JP 2023521985 A 20230526; KR 20220164521 A 20221213; LT 4132909 T 20240527; MX 2022012492 A 20230111; PL 4132909 T3 20240805; PT 4132909 T 20240502; RS 65710 B1 20240830; SI 4132909 T1 20240628; US 12109192 B2 20241008; US 2023190706 A1 20230622; WO 2021205144 A1 20211014
DOCDB simple family (application)
GB 202005112 A 20200407; AU 2021253747 A 20210331; BR 112022020198 A 20210331; CA 3173878 A 20210331; CN 202180040441 A 20210331; DK 21717172 T 20210331; EP 21717172 A 20210331; EP 24160044 A 20210331; ES 21717172 T 20210331; FI 21717172 T 20210331; GB 2021050799 W 20210331; HR P20240922 T 20210331; IL 29704522 A 20221003; JP 2022561648 A 20210331; KR 20227037233 A 20210331; LT GB2021050799 T 20210331; MX 2022012492 A 20210331; PL 21717172 T 20210331; PT 21717172 T 20210331; RS P20240763 A 20210331; SI 202130139 T 20210331; US 202117995621 A 20210331