EP 4143313 A2 20230308 - METHOD FOR IDENTIFICATION AND RELATIVE QUANTIFICATION OF NUCLEIC ACID SEQUENCE, MUTATION, COPY NUMBER, OR METHYLATION CHANGES
Title (en)
METHOD FOR IDENTIFICATION AND RELATIVE QUANTIFICATION OF NUCLEIC ACID SEQUENCE, MUTATION, COPY NUMBER, OR METHYLATION CHANGES
Title (de)
VERFAHREN ZUR IDENTIFIZIERUNG UND RELATIVEN QUANTIFIZIERUNG VON NUKLEINSÄURESEQUENZEN, MUTATION, KOPIENZAHL ODER METHYLIERUNGSÄNDERUNGEN
Title (fr)
PROCÉDÉ ET MARQUEURS POUR L'IDENTIFICATION ET LA QUANTIFICATION RELATIVE D'UNE SÉQUENCE D'ACIDE NUCLÉIQUE, D'UNE MUTATION, D'UN NOMBRE DE COPIES OU DE CHANGEMENTS DE MÉTHYLATION À L'AIDE DE COMBINAISONS DE NUCLÉASE, DE LIGATURE, DE RÉPARATION D'ADN ET DE RÉACTIONS PAR POLYMÉRASE AVEC PRÉVENTION DE RÉMANENCE
Publication
Application
Priority
- US 202063019142 P 20200501
- US 2021029998 W 20210429
Abstract (en)
[origin: WO2021222647A2] The present invention relates to methods for identifying and/or quantifying low abundance, nucleotide base mutations, insertions, deletions, translocations, splice variants, miRNA variants, alternative transcripts, alternative start sites, alternative coding sequences, alternative non-coding sequences, alternative splicings, exon insertions, exon deletions, intron insertions, or other rearrangement at the genome level and/or methylated or hydroxymethylated nucleotide bases, as well as markers to identify early cancer, monitor cancer treatment, and identify early cancer recurrence.
IPC 8 full level
C12N 15/10 (2006.01); C12Q 1/6806 (2018.01); C12Q 1/6853 (2018.01)
CPC (source: EP GB US)
C12Q 1/6853 (2013.01 - EP GB US); C12Q 1/686 (2013.01 - US); C12Q 1/6886 (2013.01 - US); C12Q 1/686 (2013.01 - EP GB); C12Q 2521/331 (2013.01 - GB); C12Q 2521/501 (2013.01 - GB); C12Q 2521/514 (2013.01 - GB); C12Q 2521/539 (2013.01 - GB); C12Q 2525/121 (2013.01 - GB); C12Q 2525/161 (2013.01 - GB); C12Q 2525/186 (2013.01 - GB); C12Q 2533/107 (2013.01 - GB); C12Q 2537/164 (2013.01 - GB); C12Q 2600/118 (2013.01 - US); C12Q 2600/154 (2013.01 - EP GB US)
C-Set (source: EP)
C12Q 1/6853 + C12Q 2521/331 + C12Q 2521/501 + C12Q 2521/514 + C12Q 2521/539 + C12Q 2525/121 + C12Q 2525/161 + C12Q 2525/186 + C12Q 2533/107 + C12Q 2537/164
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2021222647 A2 20211104; WO 2021222647 A3 20211230; AU 2021263936 A1 20221215; BR 112022022179 A2 20221213; CA 3176759 A1 20211104; EP 4143313 A2 20230308; GB 202217105 D0 20221228; GB 2611639 A 20230412; JP 2023524067 A 20230608; US 2023287484 A1 20230914
DOCDB simple family (application)
US 2021029998 W 20210429; AU 2021263936 A 20210429; BR 112022022179 A 20210429; CA 3176759 A 20210429; EP 21796698 A 20210429; GB 202217105 A 20210429; JP 2022566331 A 20210429; US 202117922589 A 20210429