EP 4146809 A1 20230315 - LARGE SCALE PRODUCTION OF OLIVETOL, OLIVETOLIC ACID AND OTHER ALKYL RESORCINOLS BY FERMENTATION
Title (en)
LARGE SCALE PRODUCTION OF OLIVETOL, OLIVETOLIC ACID AND OTHER ALKYL RESORCINOLS BY FERMENTATION
Title (de)
FERMENTATIVE HERSTELLUNG VON OLIVETOL, OLIVETOLSÄURE UND ANDEREN ALKYLRESORZINEN IM GROSSMASSSTAB
Title (fr)
PRODUCTION À GRANDE ÉCHELLE D'OLIVÉTOL, D'ACIDE OLIVÉTOLIQUE ET D'AUTRES ALKYLRÉSORCINOLS PAR FERMENTATION
Publication
Application
Priority
- US 202063022038 P 20200508
- US 202063070513 P 20200826
- US 202063079390 P 20200916
- US 202063089736 P 20201009
- US 202063122369 P 20201207
- US 2021030452 W 20210503
Abstract (en)
[origin: WO2021225952A1] Provided herein are processes, such as commercially viable processes, of producing alkyl resorcinols, such as olivetol and olivetolic acid, and analogs of each thereof. Certain of these processes utilize a recombinant, heterologous host microorganism. Certain of the heterologous microorganisms include a Cannabis sativa olivetol synthase (which is a tetraketide synthase, csOLS). Certain of the heterologous microorganisms include a Cannabis sativa olivetolic acid cyclase (csOAC). Certain of the heterologous microorganisms include a Cannabis sativa acyl activating enzyme (csAAE), such as, without limitation, csAAE1. In certain of these processes, glucose is fermented. In certain of these processes, the fermentation further comprises a carboxylic acid, RCO2H where R is defined as herein, or a salt thereof. Certain of these processes provide olivetol and olivetolic acid in a combined amount of at least 3 g/liter.
IPC 8 full level
C12N 15/81 (2006.01); C07C 63/04 (2006.01); C12N 9/10 (2006.01); C12N 9/12 (2006.01); C12N 9/88 (2006.01); C12N 15/52 (2006.01)
CPC (source: EP)
C12N 1/18 (2013.01); C12N 9/1029 (2013.01); C12N 9/88 (2013.01); C12N 9/93 (2013.01); C12N 15/52 (2013.01); C12N 15/81 (2013.01); C12P 7/22 (2013.01); C12P 7/42 (2013.01); C12Y 203/01206 (2015.07); C12Y 302/01 (2013.01); C12Y 404/01026 (2015.07); C12R 2001/865 (2021.05)
Citation (search report)
See references of WO 2021225952A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2021225952 A1 20211111; CA 3177968 A1 20211111; EP 4146809 A1 20230315
DOCDB simple family (application)
US 2021030452 W 20210503; CA 3177968 A 20210503; EP 21799490 A 20210503