EP 4151659 A1 20230322 - BIOLOGICAL MACROMOLECULAR TARGET-SPECIFIC COMPLEMENT INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Title (en)
BIOLOGICAL MACROMOLECULAR TARGET-SPECIFIC COMPLEMENT INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Title (de)
BIOLOGISCHER MAKROMOLEKULARER ZIELSPEZIFISCHER KOMPLEMENTINHIBITOR, HERSTELLUNGSVERFAHREN DAFÜR UND ANWENDUNG DAVON
Title (fr)
INHIBITEUR DU COMPLÉMENT MACROMOLÉCULAIRE BIOLOGIQUE SPÉCIFIQUE À UNE CIBLE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
Publication
Application
Priority
- CN 202010393721 A 20200511
- CN 2021092861 W 20210510
Abstract (en)
A fusion protein of a biological macromolecular target-specific complement inhibitor comprising: (i) a CRIg extracellular domain, (ii) a complement inhibiting domain, and (iii) a synergetic domain, a preparation method therefor and a use thereof, and a pharmaceutical composition comprising the fusion protein. The fusion protein not only has an obvious targeted complement inhibiting effect, but also facilitates improving druggability and/or production, and thus can be used for treating and preventing a plurality of human diseases related to abnormal complement activation.
IPC 8 full level
C07K 19/00 (2006.01); C12N 15/62 (2006.01)
CPC (source: CN EP US)
A61K 47/64 (2017.08 - CN); A61K 47/68 (2017.08 - EP); A61P 21/04 (2018.01 - CN EP US); A61P 37/02 (2018.01 - CN EP); C07K 14/472 (2013.01 - CN EP US); C07K 14/70503 (2013.01 - CN US); C07K 14/70532 (2013.01 - EP); C07K 14/70596 (2013.01 - CN EP US); C12N 15/62 (2013.01 - EP); A61K 38/00 (2013.01 - CN EP US); C07K 2319/00 (2013.01 - EP); C07K 2319/30 (2013.01 - CN EP US); C07K 2319/31 (2013.01 - CN EP US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
EP 4151659 A1 20230322; CA 3178088 A1 20211118; CN 113637084 A 20211112; CN 115515985 A 20221223; JP 2023526218 A 20230621; US 2023348554 A1 20231102; WO 2021228052 A1 20211118
DOCDB simple family (application)
EP 21804660 A 20210510; CA 3178088 A 20210510; CN 202010393721 A 20200511; CN 2021092861 W 20210510; CN 202180034009 A 20210510; JP 2022568638 A 20210510; US 202117998367 A 20210510