EP 4167958 A1 20230426 - POLYMERIC BILE ACID ESTER NANOPARTICLES COMPRISING AN IMMUNOMODULATOR AGENT TO INDUCE ANTIGEN-SPECIFIC TOLERANCE
Title (en)
POLYMERIC BILE ACID ESTER NANOPARTICLES COMPRISING AN IMMUNOMODULATOR AGENT TO INDUCE ANTIGEN-SPECIFIC TOLERANCE
Title (de)
POLYMERE GALLENSÄUREESTERNANOPARTIKEL MIT EINEM IMMUNMODULATOR ZUR INDUZIERUNG ANTIGENSPEZIFISCHER TOLERANZ
Title (fr)
NANOPARTICULES D'ESTER D'ACIDE BILIAIRE POLYMÈRE COMPRENANT UN AGENT IMMUNOMODULATEUR POUR INDUIRE UNE TOLÉRANCE SPÉCIFIQUE À L'ANTIGÈNE
Publication
Application
Priority
- US 202016907055 A 20200619
- US 2021038209 W 20210621
Abstract (en)
[origin: WO2021258042A1] Polymeric bile acid (pBA) nanoparticles and tolerogenic formulation containing polymeric bile acid nanoparticles for oral delivery and induction of antigen-specific tolerance in a subject may include immunosuppressants and/or disease-specific antigen. Oral delivery results in local organ accumulation as well as systemic delivery of the nanoparticles. Early intervention with the nanoparticles induces antigen-specific tolerance and prevents development of autoimmune disorders. Treatment with the nanoparticles results in long-term antigen-specific immune tolerance, even after cessation of treatment, in autoimmune diseases.
IPC 8 full level
A61K 9/00 (2006.01); A61K 9/16 (2006.01); A61K 9/51 (2006.01); A61K 31/436 (2006.01); A61K 38/28 (2006.01); A61K 39/00 (2006.01); A61P 3/10 (2006.01); A61P 37/06 (2006.01)
CPC (source: EP)
A61K 9/1647 (2013.01); A61K 9/5153 (2013.01); A61K 31/436 (2013.01); A61K 38/28 (2013.01); A61K 39/0008 (2013.01); A61P 3/10 (2017.12); A61P 37/06 (2017.12); A61K 2039/55511 (2013.01); A61K 2039/577 (2013.01)
Citation (search report)
See references of WO 2021258042A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2021258042 A1 20211223; CN 116600789 A 20230815; EP 4167958 A1 20230426; JP 2023532204 A 20230727
DOCDB simple family (application)
US 2021038209 W 20210621; CN 202180055989 A 20210621; EP 21742249 A 20210621; JP 2022577557 A 20210621