EP 4171736 A1 20230503 - NOVEL CELL METABOLISM MODULATING COMPOUNDS AND USES THEREOF
Title (en)
NOVEL CELL METABOLISM MODULATING COMPOUNDS AND USES THEREOF
Title (de)
NEUARTIGE VERBINDUNGEN ZUR MODULATION DES ZELLMETABOLISMUS UND VERWENDUNGEN DAVON
Title (fr)
NOUVEAUX COMPOSÉS MODULATEURS DU MÉTABOLISME CELLULAIRE ET LEURS UTILISATIONS
Publication
Application
Priority
- US 202063045079 P 20200627
- US 2021039470 W 20210628
Abstract (en)
[origin: US2022002243A1] A novel class of compounds according to Formula I, II, or III, wherein W1-W4, Z1-Z4, Z1-Z5, X, Y, n, and R1-R8 are as defined in the claims and description of embodiments that bind to fatty acid binding protein FABP4 and modulate adipocyte metabolism to drive enhanced glucose utilization, as well as pharmaceutical compositions comprising the class of compounds, in combination with a pharmaceutically acceptable diluent or carrier, and optionally, further in combination with a therapeutically active agent, and the use of these compounds in medicine and for the preparation of a medicament in the treatment of disorders acting on the FABP4. In examples, the ring Z contains Z1-Z4. In other examples, the ring Z contains Z1-Z5.
IPC 8 full level
A61P 3/08 (2006.01); A61P 3/10 (2006.01); C07D 209/10 (2006.01); C07D 209/82 (2006.01); C07D 209/94 (2006.01); C07D 403/06 (2006.01); C07D 413/06 (2006.01)
CPC (source: EP IL KR US)
A61K 31/403 (2013.01 - KR); A61K 45/06 (2013.01 - EP IL US); A61P 3/04 (2018.01 - KR); A61P 3/10 (2018.01 - EP KR); A61P 9/10 (2018.01 - KR); C07D 209/86 (2013.01 - EP IL KR US); C07D 209/94 (2013.01 - EP IL); C07D 401/06 (2013.01 - EP IL); C07D 409/06 (2013.01 - EP IL); C07B 2200/07 (2013.01 - US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
US 2022002243 A1 20220106; AU 2021297465 A1 20230302; BR 112022026550 A2 20230117; CA 3184282 A1 20211230; CN 115803085 A 20230314; EP 4171736 A1 20230503; EP 4171736 A4 20240703; IL 299002 A 20230201; JP 2023532888 A 20230801; KR 20230031322 A 20230307; MX 2023000036 A 20230201; US 2023331673 A1 20231019; WO 2021263246 A1 20211230
DOCDB simple family (application)
US 202117361052 A 20210628; AU 2021297465 A 20210628; BR 112022026550 A 20210628; CA 3184282 A 20210628; CN 202180045833 A 20210628; EP 21829660 A 20210628; IL 29900222 A 20221211; JP 2022580402 A 20210628; KR 20237003178 A 20210628; MX 2023000036 A 20210628; US 2021039470 W 20210628; US 202118012985 A 20210628