EP 4182314 A1 20230524 - METHOD FOR PREPARING A CHELATING LIGAND DERIVED FROM PCTA
Title (en)
METHOD FOR PREPARING A CHELATING LIGAND DERIVED FROM PCTA
Title (de)
VERFAHREN ZUR HERSTELLUNG EINES CHELATBILDENDEN LIGANDEN AUS PCTA
Title (fr)
PROCEDE DE PREPARATION D'UN LIGAND CHELATEUR DERIVE DE PCTA
Publication
Application
Priority
- EP 20305830 A 20200717
- EP 2021070169 W 20210719
Abstract (en)
[origin: WO2022013454A1] The present invention relates to a method for preparing the macrocyclic ligand of formula (L) comprising i) decomplexing the complex of formula (II) consisting of at least 80% of a diastereoisomeric excess comprising a mixture of isomers ll-RRR and ll-SSS of formulae (IISSS) (II-RRR), ii) eliminating the gadolinium salt formed during step i), for example by filtration, and iii) recovering the free macrocyclic ligand of formula (L). The present invention also relates to a composition comprising the diastereoisomerically enriched complex of formula (II) and the macrocyclic ligand of formula (L).
IPC 8 full level
C07D 471/08 (2006.01); C07D 471/04 (2006.01)
CPC (source: EP US)
C07D 471/04 (2013.01 - EP); C07D 471/08 (2013.01 - EP US)
Citation (search report)
See references of WO 2022013454A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2022013454 A1 20220120; CN 116209661 A 20230602; EP 4182314 A1 20230524; KR 20230041007 A 20230323; US 2023339945 A1 20231026
DOCDB simple family (application)
EP 2021070169 W 20210719; CN 202180060719 A 20210719; EP 21743521 A 20210719; KR 20237003913 A 20210719; US 202118016097 A 20210719