Global Patent Index - EP 4184528 A4

EP 4184528 A4 20240214 - METHOD FOR PRODUCING 225AC SOLUTION

Title (en)

METHOD FOR PRODUCING 225AC SOLUTION

Title (de)

VERFAHREN ZUR HERSTELLUNG EINER 125AC-LÖSUNG

Title (fr)

PROCÉDÉ DE PRODUCTION DE SOLUTION 225AC

Publication

EP 4184528 A4 20240214 (EN)

Application

EP 21842595 A 20210713

Priority

  • JP 2020123131 A 20200717
  • JP 2021026222 W 20210713

Abstract (en)

[origin: EP4184528A1] A method for producing <sup>225</sup>Ac solution includes steps (I) to (III): a step (I) of passing a solution (1) containing <sup>226</sup>Ra and <sup>225</sup>Ac through a solid-phase extraction agent (a) that contains a compound represented by formula (A) so as to cause the solid-phase extraction agent (a) to retain <sup>225</sup>Ac; a step (II) of passing a liquid containing an eluate (2), which is obtained by eluting the retained <sup>225</sup>Ac from the solid-phase extraction agent (a), through a solid-phase extraction agent (b) that contains a compound represented by formula (B) so as to cause the solid-phase extraction agent (b) to retain <sup>225</sup>Ac; and a step (III) of eluting the retained <sup>225</sup>Ac from the solid-phase extraction agent (b) to obtain an <sup>225</sup>Ac solution.[m and n each independently represent 0 or 1, and R<sup>1</sup> to R<sup>4</sup> each independently represent a linear or branched C8-C12 alkyl group.][R<sup>5</sup> and R<sup>6</sup> each independently represent a C8 alkyl group or a C8 alkoxy group.]

IPC 8 full level

B01J 20/22 (2006.01); B01J 20/32 (2006.01); B01J 20/34 (2006.01); C22B 3/24 (2006.01); C22B 3/42 (2006.01); C22B 60/02 (2006.01); G21G 1/00 (2006.01)

CPC (source: EP US)

A61K 51/121 (2013.01 - US); B01J 20/22 (2013.01 - EP); B01J 20/3208 (2013.01 - EP); B01J 20/3251 (2013.01 - EP); B01J 20/3475 (2013.01 - EP); C22B 3/24 (2013.01 - EP); C22B 3/42 (2013.01 - EP); C22B 60/0295 (2013.01 - EP); G21G 1/001 (2013.01 - EP); B01J 2220/62 (2013.01 - EP); G21G 1/0005 (2013.01 - EP); G21G 2001/0089 (2013.01 - EP); Y02P 10/20 (2015.11 - EP)

Citation (search report)

  • [XYI] MAERTENS D. ET AL: "Ra-226/Ac-225 chemical separation R&D at SCK-CEN", 11TH INTERNATIONAL SYMPOSIUM ON TARGETED ALPHA THERAPY, 4 January 2019 (2019-01-04), XP055947293
  • [YA] ANDREW KYLE HENDERSON ROBERTSON ET AL: "Development of 225 Ac Radiopharmaceuticals: TRIUMF Perspectives and Experiences", CURRENT RADIOPHARMACEUTICALS, vol. 11, no. 3, 22 October 2018 (2018-10-22), NL, pages 156 - 172, XP055736218, ISSN: 1874-4710, DOI: 10.2174/1874471011666180416161908
  • [A] OSTAPENKO V ET AL: "Extraction chromatographic behavior of actinium and REE on DGA, Ln and TRU resins in nitric acid solutions", JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, AKADEMIAI KIADO RT, HU, vol. 306, no. 3, 1 August 2015 (2015-08-01), pages 707 - 711, XP035842248, ISSN: 0236-5731, [retrieved on 20150801], DOI: 10.1007/S10967-015-4331-Y
  • See also references of WO 2022014555A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

EP 4184528 A1 20230524; EP 4184528 A4 20240214; AU 2021309611 A1 20230216; CA 3189384 A1 20220120; CN 115867684 A 20230328; JP WO2022014555 A1 20220120; KR 20230039646 A 20230321; TW 202217011 A 20220501; US 2023310665 A1 20231005; WO 2022014555 A1 20220120; ZA 202300678 B 20240530

DOCDB simple family (application)

EP 21842595 A 20210713; AU 2021309611 A 20210713; CA 3189384 A 20210713; CN 202180048807 A 20210713; JP 2021026222 W 20210713; JP 2022536364 A 20210713; KR 20237001191 A 20210713; TW 110126186 A 20210716; US 202118005129 A 20210713; ZA 202300678 A 20230116