EP 4185703 A1 20230531 - IMPROVED PROCESS FOR PRODUCTION OF CLAVULANIC ACID
Title (en)
IMPROVED PROCESS FOR PRODUCTION OF CLAVULANIC ACID
Title (de)
VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON CLAVULANSÄURE
Title (fr)
PROCÉDÉ DE PRODUCTION D'ACIDE CLAVULANIQUE
Publication
Application
Priority
- EP 20187742 A 20200724
- EP 2021070660 W 20210723
Abstract (en)
[origin: WO2022018258A1] The present invention relates to a process for the preparation of the β-lactamase inhibitor clavulanic acid by using a microorganism, comprising a step of targeted modifying said microorganism. The present invention is further directed to a process for preparing clavulanic acid by using a microorganism being capable of producing clavulanic acid, but at the same time exhibits reduced or no production of teleocidin A and/or congeners originating from the teleocidin biosynthetic pathway; to a process for preparing clavulanic acid by using a microorganism being capable of producing clavulanic acid, with this process comprising a step of testing said microorganism as to whether it is capable of producing clavulanic acid, but at the same time exhibits reduced or no production of teleocidin A, and/or other congeners originating from the teleocidin biosynthetic pathway; and to a method of testing the suitability of a strain of S. clavuligerus for being used in the production of clavulanic acid, this method comprising a step of assessing whether said strain produces teleocidin A and/or other congeners originating from the teleocidin biosynthetic pathway. The present invention further relates to a method of testing whether a culture broth that is used for culturing S. clavuligerus and producing clavulanic acid has low toxicity, comprising a step of detecting the presence or absence of teleocidin A in said culture broth. Finally, the present invention relates to S. clavuligerus that produces clavulanic acid but reduced or no teleocidin A and/or other congeners originating from the teleocidin biosynthetic pathway.
IPC 8 full level
C12N 15/52 (2006.01); C12N 15/76 (2006.01); C12P 17/18 (2006.01)
CPC (source: EP)
C12N 15/52 (2013.01); C12N 15/76 (2013.01); C12P 17/188 (2013.01)
Citation (search report)
See references of WO 2022018258A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
DOCDB simple family (application)
EP 2021070660 W 20210723; EP 21749793 A 20210723