Global Patent Index - EP 4196116 B1

EP 4196116 B1 20240710 - PHARMACEUTICAL COMPOSITION COMPRISING CABOZANTINIB, PLERIXAFOR, AFATINIB AND ETORICOXIB FOR USE IN THE TREATMENT OR PROPHYLAXIS OF NSCLC WITHOUT DRIVER MUTATIONS

Title (en)

PHARMACEUTICAL COMPOSITION COMPRISING CABOZANTINIB, PLERIXAFOR, AFATINIB AND ETORICOXIB FOR USE IN THE TREATMENT OR PROPHYLAXIS OF NSCLC WITHOUT DRIVER MUTATIONS

Title (de)

PHARMAZEUTISCHE ZUSAMMENSETZUNG, UMFASSEND CABOZANTINIB, PLERIXAFOR, AFATINIB UND ETORICOXIB ZUR VERWENDUNG BEI DER BEHANDLUNG ODER PROPHYLAXE VON NSCLC OHNE DRIVERMUTATIONEN

Title (fr)

COMPOSITION PHARMACEUTIQUE COMPRENANT DU CABOZANTINIB, DU PLERIXAFOR, DE L'AFATINIB ET DE L'ÉTORICOXIB POUR UNE UTILISATION DANS LE TRAITEMENT OU LA PROPHYLAXIE DU CPNPC SANS MUTATIONS ONCOGENIQUES

Publication

EP 4196116 B1 20240710 (EN)

Application

EP 21766393 A 20210812

Priority

  • DE 102020005002 A 20200817
  • EP 2021072486 W 20210812

Abstract (en)

[origin: WO2022038038A2] The present invention relates to a pharmaceutical composition comprising a plurality of active agents respectively inhibiting VEGF's and/or VEGFR1-3; SDF1alpha and/or CXCR4; EGF and/or EGFR1-3; COX2 and/or PGE2 and/or EP; and HGF and/or HGFR (MET), in particular for use in the treatment or prophylaxis of tumor diseases, preferably selected from the group consisting of renal cell carcinoma (RCC), hepatocellular cancer (HCC), gastrointestinal stroma tumor (GIST), colorectal cancer (CRC), gastric cancer (GC) gastro-esophageal junction cancer (GEJ), neuro-endocrine tumor (NET), non-small cell lung cancer (NSCLC), chronic myeloid leukemia (CML) acute myeloid leukemia (AML), acute lymphatic leukemia (ALL), differentiated thyroid cancer (DTC) with or without driver mutations, such as EGFRm, KRAS, FGFR, ALK, cKIT, BRAF including a respective treatment method.

IPC 8 full level

A61K 31/395 (2006.01); A61K 31/444 (2006.01); A61K 31/47 (2006.01); A61K 31/517 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01)

CPC (source: EP)

A61K 31/395 (2013.01); A61K 31/444 (2013.01); A61K 31/47 (2013.01); A61K 31/517 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01)

C-Set (source: EP)

  1. A61K 45/06 + A61K 2300/00
  2. A61K 31/47 + A61K 2300/00
  3. A61K 31/517 + A61K 2300/00
  4. A61K 31/395 + A61K 2300/00
  5. A61K 31/444 + A61K 2300/00

Citation (examination)

  • GRIDELLI C. ET AL: "Selective Cyclooxygenase-2 Inhibitors and Non-small Cell Lung Cancer", CURRENT MEDICINAL CHEMISTRY, vol. 9, no. 21, 1 November 2002 (2002-11-01), NL, pages 1851 - 1858, XP55866070, ISSN: 0929-8673, DOI: 10.2174/0929867023368863
  • JUNG M-J ET AL: "Upregulation of CXCR4 is functionally crucial for maintenance of stemness in drug-resistant non-small cell lung cancer cells", ONCOGENE, vol. 32, no. 2, 27 February 2012 (2012-02-27), London, pages 209 - 221, XP55866839, ISSN: 0950-9232, Retrieved from the Internet <URL:http://www.nature.com/articles/onc201237> DOI: 10.1038/onc.2012.37
  • LI JIANMIN ET AL: "mir-1-mediated paracrine effect of cancer-associated fibroblasts on lung cancer cell proliferation and chemoresistance", ONCOLOGY REPORTS, vol. 35, no. 6, 29 March 2016 (2016-03-29), pages 3523 - 3531, XP55866062, ISSN: 1021-335X, DOI: 10.3892/or.2016.4714
  • NADDA N. ET AL: "Angiostatic role of the selective cyclooxygenase-2 inhibitor etoricoxib (MK0663) in experimental lung cancer", BIOMEDICINE & PHARMACOTHERAPY, vol. 66, no. 6, 1 September 2012 (2012-09-01), FR, pages 474 - 483, XP55866073, ISSN: 0753-3322, DOI: 10.1016/j.biopha.2012.04.002
  • NELSON-TAYLOR SARAH ET AL: "Supplementary Figures: Resistance to RET-Inhibition in RET-Rearranged NSCLC Is Mediated By Reactivation of RAS/MAPK Signaling", 1 January 2017 (2017-01-01), XP55866520, Retrieved from the Internet <URL:https://mct.aacrjournals.org/highwire/filestream/62889/field_highwire_adjunct_files/0/176867_2_supp_3997337_mmmmyw.pdf> [retrieved on 20211126], DOI: 10.1158/1535-7163.MCT-17-0008
  • NELSON-TAYLOR SARAH K. ET AL: "Resistance to RET-Inhibition in RET-Rearranged NSCLC Is Mediated By Reactivation of RAS/MAPK Signaling", MOLECULAR CANCER THERAPEUTICS, vol. 16, no. 8, 12 May 2017 (2017-05-12), US, pages 1623 - 1633, XP55866037, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-17-0008

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

DE 102020005002 A1 20220217; EP 4196116 A2 20230621; EP 4196116 B1 20240710; EP 4196116 C0 20240710; WO 2022038038 A2 20220224; WO 2022038038 A3 20220331

DOCDB simple family (application)

DE 102020005002 A 20200817; EP 2021072486 W 20210812; EP 21766393 A 20210812