EP 4200274 A2 20230628 - BETA-HYDROXYBUTYRIC ACID COMPOSITIONS AND METHODS FOR ORAL DELIVERY OF KETONE BODIES
Title (en)
BETA-HYDROXYBUTYRIC ACID COMPOSITIONS AND METHODS FOR ORAL DELIVERY OF KETONE BODIES
Title (de)
BETA-HYDROXYBUTTERSÄURE-ZUSAMMENSETZUNGEN UND VERFAHREN ZUR ORALEN VERABREICHUNG VON KETONKÖRPERN
Title (fr)
COMPOSITIONS D'ACIDE BÊTA-HYDROXYBUTYRIQUE ET PROCÉDÉS D'ADMINISTRATION ORALE DE CORPS CÉTONIQUES
Publication
Application
Priority
- US 202016996509 A 20200818
- US 202117210646 A 20210324
- US 2021050302 W 20210914
Abstract (en)
[origin: WO2022040644A2] Beta-hydroxybutyric acid compositions for oral delivery are substantially free of beta-hydroxybutyrate salts and are effective in rapidly raising blood ketone levels without causing acute acidosis or gastrointestinal (GI) distress when consumed in sufficiently dilute form and/or as a gel or suspension. By excluding beta-hydroxybutyrate salts (e.g., less than 1% by weight) containing alkali or alkaline earth metal ions, beta-hydroxybutyric acid solutions, gels, or suspensions can deliver exogenous ketone bodies without significantly altering electrolyte balance. Although aqueous beta-hydroxybutyric acid solutions are moderately acidic with a pH of about 3.5 to 4, when diluted with sufficient water, the water acts as a pseudo buffering agent that offsets otherwise harsh acidic effects when consumed orally. Gels and suspensions can also ameliorate acidic effects by partially encapsulating the beta-hydroxybutyric acid. Beta-hydroxybutyric acid can be enriched with the R- or the S-enantiomer, a racemic mixture, pure R-beta-hydroxybutyric acid, or pure S-beta-hydroxybutyric acid.
IPC 8 full level
C07C 59/01 (2006.01); A61K 31/19 (2006.01); A61P 3/02 (2006.01); C12P 7/42 (2006.01)
CPC (source: EP)
A23L 33/10 (2016.08); A61K 9/0095 (2013.01); A61K 9/06 (2013.01); A61K 31/19 (2013.01); A61K 45/06 (2013.01); A61K 47/12 (2013.01); A61K 47/183 (2013.01); A61P 3/04 (2018.01); A61P 3/10 (2018.01); A61P 25/00 (2018.01); A61P 35/00 (2018.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2022040644 A2 20220224; WO 2022040644 A3 20220407; AU 2021327408 A1 20230420; EP 4200274 A2 20230628; EP 4200274 A4 20241023
DOCDB simple family (application)
US 2021050302 W 20210914; AU 2021327408 A 20210914; EP 21859286 A 20210914