EP 4204004 A1 20230705 - ANTI-IDIOTYPE COMPOSITIONS AND METHODS OF USE THEREOF
Title (en)
ANTI-IDIOTYPE COMPOSITIONS AND METHODS OF USE THEREOF
Title (de)
ANTI-IDIOTYP-ZUSAMMENSETZUNGEN UND VERFAHREN ZU IHRER VERWENDUNG
Title (fr)
COMPOSITIONS ANTI-IDIOTYPE ET PROCÉDÉS D'UTILISATION ASSOCIÉS
Publication
Application
Priority
- US 2020048843 W 20200831
- US 202163136177 P 20210111
- US 202163200329 P 20210301
- US 2021020922 W 20210304
- US 2021048532 W 20210831
Abstract (en)
[origin: CN116249559A] The present disclosure provides methods and compositions comprising polynucleotides comprising nucleic acids encoding anti-idiotypic polypeptides, as well as polypeptides encoded by the polynucleotides and cells comprising and expressing the polypeptides. The disclosed methods include methods of utilizing anti-idiotype polypeptides as safety switches when the anti-idiotype polypeptides are used in combination with antibodies, including approved biological antibodies that include recognized idiotypes. Certain embodiments include an anti-idiotypic polypeptide and a nucleotide encoding the anti-idiotypic polypeptide, the nucleotide including an internal domain. In some embodiments, this internal domain has a functional domain that can induce proliferation or cell death upon binding of the anti-idiotypic polypeptide to its target antibody.
IPC 8 full level
A61K 39/395 (2006.01); A61K 51/00 (2006.01); C07K 16/00 (2006.01); C07K 16/24 (2006.01); C07K 16/28 (2006.01)
CPC (source: EP)
C07K 14/7051 (2013.01); C07K 16/2863 (2013.01); C07K 16/4208 (2013.01); C12N 15/62 (2013.01); C07K 2317/21 (2013.01); C07K 2317/622 (2013.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
DOCDB simple family (application)
CN 202180052913 A 20210831; EP 21862987 A 20210831