EP 4204448 A2 20230705 - ANTI-GOLPH2 ANTIBODIES FOR MACROPHAGE AND DENDRITIC CELL DIFFERENTIATION
Title (en)
ANTI-GOLPH2 ANTIBODIES FOR MACROPHAGE AND DENDRITIC CELL DIFFERENTIATION
Title (de)
ANTI-GOLPH2-ANTIKÖRPER ZUR MAKROPHAGEN- UND DENDRITISCHEN ZELLDIFFERENZIERUNG
Title (fr)
ANTICORPS ANTI-GOLPH2 POUR LA DIFFÉRENCIATION DES MACROPHAGES ET DES CELLULES DENDRITIQUES
Publication
Application
Priority
- EP 20193168 A 20200827
- EP 2021073781 W 20210827
Abstract (en)
[origin: WO2022043517A2] The present invention relates to target-binding molecules, preferably antibodies or target-binding fragments thereof, that specifically bind to the extracellular part GOLPH2, or to an antigenic portion thereof, wherein the binding of the target-binding molecule to the extracellular part of GOLPH2, when expressed on a monocyte or monocyte-derived cell, induces the maturation of said monocyte or monocyte-derived cell. The invention further relates to immunoconjugates comprising the target-binding molecules, in particular the anti-GOLPH2 antibodies, or target-binding fragments thereof. The target-binding molecules and immunoconjugates of the invention may be administered alone, as a therapeutic conjugate or in combination with other therapeutic agents, such as chemotherapeutic agents, antigens, vaccines or checkpoint inhibitors. The present invention also relates to nucleotide sequences encoding the target-binding molecule of the invention, as well as vectors and host cells containing the nucleotide sequences. The target-binding molecules, antibodies and compositions of the invention are useful in initiating and/or enhancing an immune response in a subject. Further, the target-binding molecule may be used in methods for generating antigen-presenting cells and activated T cell.
IPC 8 full level
C07K 16/18 (2006.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C07K 16/28 (2006.01)
CPC (source: EP)
A61K 39/0011 (2013.01); A61P 35/00 (2018.01); C07K 16/18 (2013.01); C07K 16/28 (2013.01); A61K 2039/6056 (2013.01); C07K 2317/31 (2013.01); C07K 2317/52 (2013.01); C07K 2317/622 (2013.01); C07K 2317/77 (2013.01); C12N 2710/20034 (2013.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2022043517 A2 20220303; WO 2022043517 A3 20220616; EP 4204448 A2 20230705
DOCDB simple family (application)
EP 2021073781 W 20210827; EP 21769136 A 20210827