EP 4218831 A4 20240306 - METHOD FOR PRODUCING RADIOACTIVE LABELED SUBSTANCE, DEVICE FOR PRODUCING RADIOACTIVE LABELED SUBSTANCE, AND METHOD FOR EVAPORATING AND CONCENTRATING RADIOACTIVE METAL NUCLIDE
Title (en)
METHOD FOR PRODUCING RADIOACTIVE LABELED SUBSTANCE, DEVICE FOR PRODUCING RADIOACTIVE LABELED SUBSTANCE, AND METHOD FOR EVAPORATING AND CONCENTRATING RADIOACTIVE METAL NUCLIDE
Title (de)
VERFAHREN ZUR HERSTELLUNG EINER RADIOAKTIV MARKIERTEN SUBSTANZ, VORRICHTUNG ZUR HERSTELLUNG EINER RADIOAKTIV MARKIERTEN SUBSTANZ UND VERFAHREN ZUR VERDAMPFUNG UND KONZENTRATION VON RADIOAKTIVEM METALLNUKLID
Title (fr)
PROCÉDÉ DE PRODUCTION D'UNE SUBSTANCE MARQUÉE RADIOACTIVE, DISPOSITIF DE PRODUCTION D'UNE SUBSTANCE MARQUÉE RADIOACTIVE, ET PROCÉDÉ D'ÉVAPORATION ET DE CONCENTRATION DE NUCLÉIDE MÉTALLIQUE RADIOACTIF
Publication
Application
Priority
- JP 2020162407 A 20200928
- JP 2021025827 W 20210708
Abstract (en)
[origin: EP4218831A1] The present invention is a method for evaporatively concentrating a radioactive metal nuclide, including: a first evaporative concentration process in which a radioactive solution formed by dissolving a radioactive metal nuclide in an acidic aqueous solution is heated to evaporate a solvent in the radioactive solution so as to obtain a concentrated liquid containing the radioactive metal nuclide; and a second evaporative concentration process in which a low-boiling organic solvent having a lower boiling point than water is added to the concentrated liquid, and the concentrated liquid is heated to induce azeotropic boiling of the concentrated liquid and the low-boiling organic solvent so as to obtain an evaporative concentrate of the radioactive metal nuclide. According to the present invention, it is possible to perform, without manual intervention, the processing from the separation of a radioactive metal nuclide from a radioactive solution formed by dissolving the radioactive metal nuclide in an acidic aqueous solution, to the production of a radioactive labeled substance by causing the radioactive metal nuclide to react with a label-target compound.
IPC 8 full level
G21G 1/00 (2006.01); A61K 51/00 (2006.01); B01D 1/00 (2006.01); B01D 3/36 (2006.01); A61K 103/00 (2006.01)
CPC (source: EP US)
B01D 1/14 (2013.01 - US); B01D 3/085 (2013.01 - EP); B01D 3/106 (2013.01 - EP); B01D 3/36 (2013.01 - EP US); C07B 59/004 (2013.01 - EP US); G21G 1/001 (2013.01 - EP); C07B 2200/05 (2013.01 - EP US); Y02P 10/20 (2015.11 - EP)
Citation (search report)
- [A] JP 2017502971 A 20170126
- [A] JP 2010505776 A 20100225
- [A] US 2012251415 A1 20121004 - KABAI EVA [DE], et al
- [A] EP 2562150 B1 20141015 - FUTURECHEMISTRY HOLDING B V [NL], et al
- [A] KR 100902547 B1 20090615
- [A] MATARRESE M ET AL: "Automated production of copper radioisotopes and preparation of high specific activity [64Cu]Cu-ATSM for PET studies", APPLIED RADIATION AND ISOTOPES, ELSEVIER, OXFORD, GB, vol. 68, no. 1, 1 January 2010 (2010-01-01), pages 5 - 13, XP026764221, ISSN: 0969-8043, [retrieved on 20090825], DOI: 10.1016/J.APRADISO.2009.08.010
- See also references of WO 2022064812A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
EP 4218831 A1 20230802; EP 4218831 A4 20240306; CN 116075344 A 20230505; JP WO2022064812 A1 20220331; US 2023357100 A1 20231109; WO 2022064812 A1 20220331
DOCDB simple family (application)
EP 21871944 A 20210708; CN 202180062460 A 20210708; JP 2021025827 W 20210708; JP 2022551152 A 20210708; US 202118025090 A 20210708