EP 4234542 A1 20230830 - A PROCESS FOR MANUFACTURING HIGH PURITY HYDROCHLOROTHIAZIDE
Title (en)
A PROCESS FOR MANUFACTURING HIGH PURITY HYDROCHLOROTHIAZIDE
Title (de)
VERFAHREN ZUR HERSTELLUNG VON HOCHREINEM HYDROCHLOROTHIAZID
Title (fr)
PROCÉDÉ DE FABRICATION D'HYDROCHLOROTHIAZIDE DE HAUTE PURETÉ
Publication
Application
Priority
EP 22461507 A 20220228
Abstract (en)
The present invention relates to a process for manufacturing high purity hydrochlorothiazide. In particular the present invention relates to a process for reducing amount of 6-chloro-4-nitroso-3,4-dihydro-2H-1,2,4-benzothiadiazide-7-sulfonamide-1,1-dioxide in a particulate hydrochlorothiazide and/or improving stability of a particulate hydrochlorothiazide against formation of 6-chloro-4-nitroso-3,4-dihydro-2H-1,2,4-benzothiadiazide-7-sulfonamide-1,1-dioxide, wherein a particulate hydrochlorothiazide is subjected to a treatment with a basic agent.
IPC 8 full level
C07D 285/28 (2006.01)
CPC (source: EP)
C07D 285/28 (2013.01)
Citation (applicant)
- US 3163645 A 19641229 - DE STEVENS GEORGE, et al
- US 3227710 A 19660104 - OSKAR BUB
- US 3267095 A 19660816
- US 3043840 A 19620710 - DOWNING JR GEORGE V
- US 3164588 A 19650105
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- CN 1421441 A 20030604 - BEIJING RUIKANG MEDICINE TECHN [CN]
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- B. GOLDS. MIRVISH, TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 40, 1977, pages 131 - 136
- YURII A. SIMONOV ET AL.: "Nitrosation of hydrochlorothiazide and the modes of binding of the N-nitroso derivative with two macrocycles possessing an 18-membered crown ether cavity", TETRAHEDRON, vol. 26, 2005, pages 6596 - 6601
- "Handbook of Pharmaceutical Excipients", 2020, PHARMACEUTICAL PRESS
Citation (search report)
- [XDY] US 3043840 A 19620710 - DOWNING JR GEORGE V
- [AD] WO 2009150497 A1 20091217 - ALEMBIC LTD [IN], et al
- [A] CN 105272937 A 20160127 - CHANGZHOU PHARMACEUTICAL FACTORY
- [Y] US 2020246745 A1 20200806 - LAIL MARTY [US], et al
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
DOCDB simple family (application)
EP 22461507 A 20220228; EP 2023054878 W 20230227