EP 4237078 A1 20230906 - NKD2 AS TARGET FOR TREATING RENAL FIBROSIS
Title (en)
NKD2 AS TARGET FOR TREATING RENAL FIBROSIS
Title (de)
NKD2 ALS TARGET ZUR BEHANDLUNG VON NIERENFIBROSE
Title (fr)
NOUVELLE CIBLE POUR LE TRAITEMENT DE LA FIBROSE RÉNALE
Publication
Application
Priority
- DE 102020128677 A 20201030
- EP 2021080068 W 20211028
Abstract (en)
[origin: WO2022090434A1] The present application relates to the identification of the role of the protein derived from the naked cuticle homolog 2 (Nkd2) gene in the development of chronic kidney diseases, in particular advanced chronic kidney disease and renal fibrosis. The present invention relates in particular to a method for identifying compounds which bind to the nkd2 protein and to the use of Nkd2 for screening and for identifying Nkd2-interacting compounds. The invention furthermore relates to pharmaceutical compositions for use in the treatment of kidney diseases, in particular pharmaceutical compositions comprising active substances which bind to and/or inhibit the NKD2 protein (figure 1a).
IPC 8 full level
A61P 13/12 (2006.01); A61K 38/00 (2006.01); C07K 14/435 (2006.01); G01N 33/50 (2006.01)
CPC (source: EP KR)
A61K 31/7088 (2013.01 - KR); A61K 39/395 (2013.01 - KR); A61K 48/00 (2013.01 - KR); A61P 13/12 (2017.12 - EP KR); C07K 14/435 (2013.01 - EP KR); C07K 16/18 (2013.01 - KR); G01N 33/5044 (2013.01 - EP KR); G01N 33/6872 (2013.01 - EP KR); A61K 2039/505 (2013.01 - KR); G01N 2800/347 (2013.01 - EP KR)
Citation (search report)
See references of WO 2022090434A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2022090434 A1 20220505; CA 3195914 A1 20220505; CN 116783210 A 20230919; DE 102020128677 A1 20220505; EP 4237078 A1 20230906; JP 2023549706 A 20231129; KR 20230098243 A 20230703
DOCDB simple family (application)
EP 2021080068 W 20211028; CA 3195914 A 20211028; CN 202180087798 A 20211028; DE 102020128677 A 20201030; EP 21802638 A 20211028; JP 2023526269 A 20211028; KR 20237017649 A 20211028