EP 4240279 A1 20230913 - MICROFLUIDIC DEVICES AND METHODS FOR THE DEVELOPMENT OF NEURAL TUBE-LIKE TISSUES OR NEURAL SPHEROIDS
Title (en)
MICROFLUIDIC DEVICES AND METHODS FOR THE DEVELOPMENT OF NEURAL TUBE-LIKE TISSUES OR NEURAL SPHEROIDS
Title (de)
MIKROFLUIDISCHE VORRICHTUNGEN UND VERFAHREN ZUR ENTWICKLUNG VON NEURALROHRARTIGEN GEWEBEN ODER NEURALEN SPHÄROIDEN
Title (fr)
DISPOSITIFS MICROFLUIDIQUES ET PROCÉDÉS DE DÉVELOPPEMENT DE TISSUS DU TYPE TUBE NEURAL OU SPHÉROÏDES NEURAUX
Publication
Application
Priority
- US 202063109407 P 20201104
- US 2021058090 W 20211104
Abstract (en)
[origin: WO2022098895A1] The present disclosure provides devices and in vitro methods of developing three-dimensional neural tube-like tissues. In some aspects, the disclosure provides devices and methods of developing three-dimensional neural tube-like tissues comprising forebrain-like, midbrain-like, hindbrain-like, and spinal cord-like tissues. In particular, provided herein microfluidic devices and methods of using the same for generating neural tube-like tissues, such as neural-tube like tissues comprising forebrain-like, midbrain-like, hindbrain-like, and spinal cord-like tissues. In some embodiments, uses of such neural tube-like tissues for research, compound screening and analysis, disease modeling, and therapeutics are provided.
IPC 8 full level
A61F 2/04 (2013.01); A61F 2/07 (2013.01); A61K 35/30 (2015.01); B01L 3/00 (2006.01); C12N 5/00 (2006.01); F04B 43/02 (2006.01); F04B 43/08 (2006.01)
CPC (source: EP)
A61K 35/30 (2013.01); C12N 5/0068 (2013.01); C12N 5/0618 (2013.01); C12N 5/0697 (2013.01); C12N 2513/00 (2013.01); C12N 2535/00 (2013.01)
Citation (search report)
See references of WO 2022098895A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
DOCDB simple family (application)
US 2021058090 W 20211104; EP 21890078 A 20211104