EP 4240423 A1 20230913 - MODIFIED URICASE AND USES THEREOF
Title (en)
MODIFIED URICASE AND USES THEREOF
Title (de)
MODIFIZIERTE URICASE UND VERWENDUNGEN DAVON
Title (fr)
URICASE MODIFIÉE ET SES UTILISATIONS
Publication
Application
Priority
- US 202063108890 P 20201103
- IL 2021051305 W 20211103
Abstract (en)
[origin: WO2022097141A1] A modified uricase is described herein, as well as a method of reducing a level of uric acid by contacting a medium with the modified uricase. The modified uricase comprises a uricase polypeptide crosslinked by at least one bifunctional linking moiety that comprises a poly(alkylene glycol) moiety. A molecular weight of the bifunctional linking moiety is from about 1.5 kDa to about 4 kDa, and/or the modified uricase comprises a plurality of polypeptides having the amino acid sequence SEQ ID NO: 2. Further described is a polypeptide having the amino acid sequence SEQ ID NO: 2. A process of preparing the modified uricase is also described, comprising contacting the polypeptide with a crosslinking agent that comprises a poly(alkylene glycol) moiety and at least two aldehyde groups, to obtain a conjugate; and contacting the conjugate with a reducing agent.
IPC 8 full level
A61K 47/60 (2017.01); A61P 13/12 (2006.01); C12N 9/02 (2006.01); C12N 9/06 (2006.01); C12N 9/96 (2006.01)
CPC (source: EP IL KR US)
A61K 38/00 (2013.01 - IL); A61K 38/44 (2013.01 - KR US); A61K 47/60 (2017.08 - EP IL KR); A61P 13/12 (2018.01 - EP IL KR); C12N 9/0048 (2013.01 - EP IL KR US); C12N 9/0093 (2013.01 - EP IL); C12N 9/96 (2013.01 - EP IL); C12Y 107/03003 (2013.01 - EP IL US); C12Y 114/13013 (2013.01 - EP IL); A61K 38/00 (2013.01 - EP); C12Y 107/03003 (2013.01 - KR); Y02A 50/30 (2018.01 - EP IL)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2022097141 A1 20220512; CA 3197108 A1 20220512; CN 117098559 A 20231121; EP 4240423 A1 20230913; IL 302628 A 20230701; JP 2023548496 A 20231117; KR 20230110281 A 20230721; MX 2023005235 A 20231016; US 2024002814 A1 20240104
DOCDB simple family (application)
IL 2021051305 W 20211103; CA 3197108 A 20211103; CN 202180088623 A 20211103; EP 21823682 A 20211103; IL 30262823 A 20230503; JP 2023526588 A 20211103; KR 20237018900 A 20211103; MX 2023005235 A 20211103; US 202118035149 A 20211103