Global Patent Index - EP 4249917 A3

EP 4249917 A3 20231108 - DIAGNOSTIC METHODS FOR TRIPLE-NEGATIVE BREAST CANCER

Title (en)

DIAGNOSTIC METHODS FOR TRIPLE-NEGATIVE BREAST CANCER

Title (de)

DIAGNOSEMETHODEN FÜR DREIFACH-NEGATIVEN BRUSTKREBS

Title (fr)

MÉTHODES DE DIAGNOSTIC DU CANCER DU SEIN TRIPLE NÉGATIF

Publication

EP 4249917 A3 20231108 (EN)

Application

EP 23170037 A 20190919

Priority

  • US 201862734677 P 20180921
  • US 201962837507 P 20190423
  • US 201962848163 P 20190515
  • EP 19780486 A 20190919
  • US 2019051984 W 20190919

Abstract (en)

The invention provides methods and compositions for diagnosing and treating locally advanced or metastatic breast cancer (e.g., TNBC). In some embodiments, the methods include determining the presence and/or expression level of one or more of PD-L1, CD8, and/or stromal tumor-infiltrating lymphocytes (sTILs). Provided herein are methods for identifying a patient suffering from a locally advanced or metastatic TNBC who is likely to respond to treatment with an anti-cancer therapy that includes a PD-1 axis binding antagonist (e.g., an anti-PD-L1 antibody (e.g., atezolizumab) or an anti-PD-1 antibody) and a taxane (e.g., nab-paclitaxel or paclitaxel). Also provided are methods of selecting a therapy for a patient suffering from a locally advanced or metastatic TNBC. Further provided are methods of treating a patient suffering from locally advanced or metastatic TNBC. In some embodiments, the methods include administering a PD-1 axis binding antagonist (e.g., atezolizumab) and a taxane (e.g., nab-paclitaxel or paclitaxel) to the patient, for example, a patient identified as one who is likely to respond to the treatment. Also provided are pharmaceutical compositions for use in treating a patient suffering from locally advanced or metastatic TNBC.

IPC 8 full level

G01N 33/574 (2006.01)

CPC (source: EP IL KR US)

A61K 31/337 (2013.01 - KR); A61K 39/39558 (2013.01 - US); A61P 35/00 (2018.01 - KR US); G01N 33/57415 (2013.01 - EP IL KR US); G01N 33/57492 (2013.01 - EP IL KR); A61K 2039/505 (2013.01 - KR); G01N 2800/52 (2013.01 - KR US)

Citation (search report)

  • [Y] US 2015071910 A1 20150312 - KOWANETZ MARCIN [US], et al
  • [Y] EP 3309174 A1 20180418 - GENENTECH INC [US], et al
  • [Y] WO 2017004092 A1 20170105 - SYNDAX PHARMACEUTICALS INC [US]
  • [Y] WO 2016205320 A1 20161222 - GENENTECH INC [US], et al
  • [Y] WO 2018064299 A1 20180405 - GENENTECH INC [US]
  • [A] IOANNIS A VOUTSADAKIS: "Immune Blockade Inhibition in Breast Cancer", ANTICANCER RESEARCH - INTERNATIONAL JOURNAL OF CANCER RESEARCH AND TREATMENT, vol. 36, no. 11, 1 November 2016 (2016-11-01), GR, pages 5607 - 5622, XP055652867, ISSN: 0250-7005, DOI: 10.21873/anticanres.11145
  • [A] JI HYUN PARK ET AL: "How shall we treat early triple-negative breast cancer (TNBC): from the current standard to upcoming immuno-molecular strategies", ESMO OPEN, vol. 3, no. Suppl 1, 3 May 2018 (2018-05-03), pages e000357, XP055652869, DOI: 10.1136/esmoopen-2018-000357
  • [Y] HOFFMANN F ET AL: "Media Release Phase III IMpassion130 study showed Roche's Tecentriq plus Abraxane significantly reduced the risk of disease worsening or death in people with metastatic triple negative breast cancer x First Phase III immunotherapy study to demonstrate a statistically significant improvement in", 2 July 2018 (2018-07-02), XP055941912, Retrieved from the Internet <URL:https://www.roche.com/media/releases/med-cor-2018-07-02> [retrieved on 20220713]

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2020061349 A1 20200326; WO 2020061349 A8 20200423; AU 2019342133 A1 20210422; CA 3111809 A1 20200326; EP 3857230 A1 20210804; EP 3857230 B1 20230607; EP 4249917 A2 20230927; EP 4249917 A3 20231108; ES 2955032 T3 20231128; IL 281556 A 20210531; JP 2022500638 A 20220104; JP 7475336 B2 20240426; KR 20210062634 A 20210531; MX 2021003213 A 20210512; PL 3857230 T3 20231016; TW 202104899 A 20210201; US 2021208145 A1 20210708

DOCDB simple family (application)

US 2019051984 W 20190919; AU 2019342133 A 20190919; CA 3111809 A 20190919; EP 19780486 A 20190919; EP 23170037 A 20190919; ES 19780486 T 20190919; IL 28155621 A 20210316; JP 2021513826 A 20190919; KR 20217008086 A 20190919; MX 2021003213 A 20190919; PL 19780486 T 20190919; TW 108134025 A 20190920; US 202117207165 A 20210319