EP 4251645 A1 20231004 - CELLULAR THERAPEUTICS ENGINEERED WITH SIGNAL MODULATORS AND METHODS OF USE THEREOF
Title (en)
CELLULAR THERAPEUTICS ENGINEERED WITH SIGNAL MODULATORS AND METHODS OF USE THEREOF
Title (de)
MIT SIGNALMODULATOREN MANIPULIERTE ZELLULÄRE THERAPEUTIKA UND VERFAHREN ZUR VERWENDUNG DAVON
Title (fr)
AGENTS THÉRAPEUTIQUES CELLULAIRES MODIFIÉS PAR DES MODULATEURS DE SIGNAL ET LEURS MÉTHODES D'UTILISATION
Publication
Application
Priority
- US 202063118008 P 20201125
- US 2021060833 W 20211124
Abstract (en)
[origin: US2022162288A1] The present disclosure is directed to an engineered protein (e.g., a chimeric protein) comprising one or more of an extracellular domain, a transmembrane domain and/or an intracellular domain, which are capable of binding a negative signal and functioning as a sink, dominant negative, or signal inverter for the negative signal. The disclosure is further directed to methods of generating a modified cell expressing one or more of the engineered proteins (e.g., chimeric proteins), and methods of using the modified cells in treating a disease or a condition in a subject in need thereof.
IPC 8 full level
C07K 14/705 (2006.01); A61K 38/17 (2006.01); C07K 14/54 (2006.01); C07K 14/715 (2006.01); C12N 5/0783 (2010.01)
CPC (source: EP US)
A61K 35/17 (2013.01 - US); A61K 39/4613 (2023.05 - EP); A61K 39/4644 (2023.05 - EP); A61P 35/00 (2018.01 - EP); C07K 14/4705 (2013.01 - US); C07K 14/5443 (2013.01 - EP); C07K 14/70503 (2013.01 - EP); C07K 14/71 (2013.01 - US); C07K 14/715 (2013.01 - EP); C07K 14/7155 (2013.01 - EP); C12N 5/0646 (2013.01 - EP); A61K 2239/31 (2023.05 - EP); A61K 2239/38 (2023.05 - EP); C07K 2319/03 (2013.01 - EP US); C12N 2510/00 (2013.01 - EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
US 2022162288 A1 20220526; AU 2021388155 A1 20230615; EP 4251645 A1 20231004; WO 2022115611 A1 20220602
DOCDB simple family (application)
US 202117535071 A 20211124; AU 2021388155 A 20211124; EP 21830372 A 20211124; US 2021060833 W 20211124