EP 4255501 A1 20231011 - METHODS FOR ENHANCING THERAPEUTIC EFFICACY OF ISOLATED CELLS FOR CELL THERAPY
Title (en)
METHODS FOR ENHANCING THERAPEUTIC EFFICACY OF ISOLATED CELLS FOR CELL THERAPY
Title (de)
VERFAHREN ZUR ERHÖHUNG DER THERAPEUTISCHEN WIRKSAMKEIT ISOLIERTER ZELLEN FÜR DIE ZELLTHERAPIE
Title (fr)
MÉTHODES D'AMÉLIORATION DE L'EFFICACITÉ THÉRAPEUTIQUE DE CELLULES ISOLÉES POUR LA THÉRAPIE CELLULAIRE
Publication
Application
Priority
- US 202063119708 P 20201201
- IL 2021051426 W 20211201
Abstract (en)
[origin: WO2022118310A1] This disclosure relates to methods for enhancing the therapeutic efficacy of isolated cells for use in cell therapies such as adoptive cell transfer therapies by insertion of an under¬ expressed miRNA that is beneficial for therapeutic efficacy of cell therapies into the actively expressed locus of a gene, either protein coding or non-coding, that hampers therapeutic efficacy of cell therapies by this disrupting expression of the latter while inducing expression of the former.
IPC 8 full level
A61K 48/00 (2006.01); A61K 31/7105 (2006.01); A61K 31/713 (2006.01); A61K 35/12 (2015.01); A61K 35/17 (2015.01); A61K 35/407 (2015.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C12N 5/10 (2006.01); C12N 15/11 (2006.01)
CPC (source: EP KR US)
A61K 31/7105 (2013.01 - EP); A61K 31/713 (2013.01 - EP); A61K 35/28 (2013.01 - EP); A61K 35/407 (2013.01 - EP); A61K 39/39 (2013.01 - EP); A61K 39/4611 (2023.05 - EP KR US); A61K 39/4631 (2023.05 - EP KR US); A61K 39/464412 (2023.05 - EP KR US); A61P 35/00 (2018.01 - EP KR); C12N 5/0636 (2013.01 - EP KR US); C12N 9/22 (2013.01 - EP KR US); C12N 15/113 (2013.01 - EP KR US); C12N 2310/141 (2013.01 - EP KR US); C12N 2310/20 (2017.05 - EP KR); C12N 2310/315 (2013.01 - EP); C12N 2310/321 (2013.01 - EP); C12N 2310/344 (2013.01 - EP); C12N 2510/00 (2013.01 - EP KR)
C-Set (source: EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2022118310 A1 20220609; AU 2021392094 A1 20230706; CA 3200741 A1 20220609; CN 117460541 A 20240126; EP 4255501 A1 20231011; JP 2024501151 A 20240111; KR 20230116898 A 20230804; US 2024010977 A1 20240111
DOCDB simple family (application)
IL 2021051426 W 20211201; AU 2021392094 A 20211201; CA 3200741 A 20211201; CN 202180089511 A 20211201; EP 21900217 A 20211201; JP 2023533308 A 20211201; KR 20237022375 A 20211201; US 202318327092 A 20230601