EP 4257667 A1 20231011 - DEVICE ASSEMBLY AND METHOD FOR CALIBRATING A SINGLE-USE SENSOR
Title (en)
DEVICE ASSEMBLY AND METHOD FOR CALIBRATING A SINGLE-USE SENSOR
Title (de)
VORRICHTUNG UND VERFAHREN ZUM KALIBRIEREN EINES EINMAL-SENSORS
Title (fr)
ENSEMBLE DISPOSITIF ET PROCÉDÉ D'ÉTALONNAGE D'UN CAPTEUR À USAGE UNIQUE
Publication
Application
Priority
EP 22167033 A 20220406
Abstract (en)
A device assembly (10) for calibrating a single-use sensor (14) before, during or after a biopharmaceutical manufacturing process step comprises a single-use process equipment assembly for performing at least a part of the process step. The single-use process equipment assembly includes a flow line (12) through which a medium flows in a defined direction during the process step. The single-use process equipment assembly further includes an integrated single-use sensor (14) for measuring or detecting a physical or chemical property at a measurement location in the flow line (12). The device assembly (10) further comprises at least one calibration line (18) and at least one switching means (22) inserted into the flow line (12) upstream of the measurement location. The switching means (22) include a flow line inlet, a flow line outlet and a calibration line inlet connected to the calibration line (18). The switching means (22) are adapted to selectively switch between a first (main) flow path, in which the flow line inlet (26) and the flow line outlet (28) are opened while the calibration line inlet (30) is closed, and a second (calibration) flow path, in which the flow line inlet (26) is closed while the calibration line inlet (30) and the flow line outlet (28) are opened. The device assembly (10) comprises a dedicated reference means provided in the calibration line (18). The dedicated reference means includes a reference sensor (48) or a reference source or a reference standard solution (40) related to the physical or chemical property to be measured or detected by the single-use sensor (14). The calibration line (20) may also be provided downstream of the single-use sensor (14).
IPC 8 full level
C12M 1/34 (2006.01)
CPC (source: EP)
C12M 41/00 (2013.01); C12M 23/28 (2013.01)
Citation (applicant)
WO 2020079101 A1 20200423 - GE HEALTHCARE BIO SCIENCES AB [SE]
Citation (search report)
- [YD] WO 2020079101 A1 20200423 - GE HEALTHCARE BIO SCIENCES AB [SE]
- [Y] WO 2007129463 A2 20071115 - NIKKISO CO LTD [JP], et al
- [A] EP 2689237 A1 20140129 - PARKER HANNIFIN CORP [US]
- [A] US 2016298988 A1 20161013 - HAHN THOMAS [DE], et al
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
DOCDB simple family (application)
EP 22167033 A 20220406; EP 2023058977 W 20230405