EP 4262978 A1 20231025 - CHEMICAL COMPOUNDS USEFUL FOR INHIBITING NAV1.8 VOLTAGE-GATED SODIUM CHANNELS AND TREATING NAV1.8 MEDIATED DISEASES
Title (en)
CHEMICAL COMPOUNDS USEFUL FOR INHIBITING NAV1.8 VOLTAGE-GATED SODIUM CHANNELS AND TREATING NAV1.8 MEDIATED DISEASES
Title (de)
CHEMISCHE VERBINDUNGEN ZUR HEMMUNG VON NAV1.8-SPANNUNGSGESTEUERTEN NATRIUMKANÄLEN UND ZUR BEHANDLUNG VON NAV1.8-VERMITTELTEN ERKRANKUNGEN
Title (fr)
COMPOSÉS CHIMIQUES UTILES POUR INHIBER LES CANAUX SODIQUES SENSIBLES À LA TENSION NAV1.8 ET TRAITER LES MALADIES MÉDIÉES PAR NAV1.8
Publication
Application
Priority
- US 202063127341 P 20201218
- EP 2021086101 W 20211216
Abstract (en)
[origin: WO2022129283A1] Compounds of formula (I) are described, wherein each of the variable groups is as defined in the specification. Also described are pharmaceutical compositions containing a compound of formula (I), and uses of the compounds and pharmaceutical compositions for inhibiting Nav1.8 voltage-gated sodium channels and treating Nav1.8 mediated diseases, disorders, and conditions, such as pain and pain-associated diseases, disorders, and conditions and cardiovascular diseases, disorders, and conditions.(I)
IPC 8 full level
A61P 3/12 (2006.01); A61P 9/00 (2006.01); A61P 29/00 (2006.01); C07F 9/6561 (2006.01)
CPC (source: EP IL KR)
A61K 31/675 (2013.01 - KR); A61P 3/12 (2018.01 - EP IL KR); A61P 9/00 (2018.01 - EP IL KR); A61P 29/00 (2018.01 - EP IL KR); C07F 9/6561 (2013.01 - EP IL KR)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2022129283 A1 20220623; AU 2021403606 A1 20230622; CA 3202328 A1 20220623; CL 2023001750 A1 20240119; CN 116710463 A 20230905; CO 2023008049 A2 20230630; EP 4262978 A1 20231025; IL 303795 A 20230801; JP 2024502231 A 20240118; KR 20230121827 A 20230821; MX 2023007244 A 20230629
DOCDB simple family (application)
EP 2021086101 W 20211216; AU 2021403606 A 20211216; CA 3202328 A 20211216; CL 2023001750 A 20230615; CN 202180085151 A 20211216; CO 2023008049 A 20230621; EP 21831047 A 20211216; IL 30379523 A 20230615; JP 2023536951 A 20211216; KR 20237023878 A 20211216; MX 2023007244 A 20211216